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Histoplasmosis is a fungal infection caused by Histoplasma capsulatum. [2] [3] Symptoms of this infection vary greatly, but the disease affects primarily the lungs. [4] Occasionally, other organs are affected; called disseminated histoplasmosis, it can be fatal if left untreated.
Histoplasma species have two forms: their environmental form is hyphal with microconidia and tuberculate macroconidia while their pathogenic form is a small intracellular yeast that exhibits narrow-necked budding [3] and no capsule.
Histoplasma capsulatum is a species of dimorphic fungus.Its sexual form is called Ajellomyces capsulatus.It can cause pulmonary and disseminated histoplasmosis.. Histoplasma capsulatum is "distributed worldwide, except in Antarctica, but most often associated with river valleys" [1] and occurs chiefly in the "Central and Eastern United States" [2] followed by "Central and South America, and ...
The diagnosis of POHS is based on the clinical triad of multiple white, atrophic choroidal scars, peripapillary pigment changes (dark spots around optic disc of the eye), and a maculopathy caused by choroidal neovascularization. Completely distinct from POHS, acute ocular histoplasmosis may rarely occur in immunodeficiency. [1] [2]
Progressive disseminated histoplasmosis is an infection caused by Histoplasma capsulatum, and most people who develop this severe form of histoplasmosis are immunocompromised or taking systemic corticosteroids. [1]: 316 Skin lesions are present in approximately 6% of patients with dissemination. [1]: 316
Hepatosplenomegaly (commonly abbreviated HSM) is the simultaneous enlargement of both the liver (hepatomegaly) and the spleen (splenomegaly).Hepatosplenomegaly can occur as the result of acute viral hepatitis, infectious mononucleosis, and histoplasmosis or it can be the sign of a serious and life-threatening lysosomal storage disease.
The test cannot diagnose autism spectrum disorder, nor is it designed to be used on its own. Instead, it is meant to help physicians rule out autism in children who have higher likelihoods of it ...
A NASA illustration of a lateral flow assay. A lateral flow test (LFT), [1] is an assay also known as a lateral flow immunochromatographic test (ICT), or rapid test.It is a simple device intended to detect the presence of a target substance in a liquid sample without the need for specialized and costly equipment.