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Answers to NYT's The Mini Crossword for Wednesday, January 15, 2025 Don't go any further unless you want to know exactly what the correct words are in today's Mini Crossword. NYT Mini Across Answers
The tumor necrosis factor (TNF) superfamily is a protein superfamily of type II transmembrane proteins containing TNF homology domain and forming trimers. Members of this superfamily can be released from the cell membrane by extracellular proteolytic cleavage and function as a cytokine .
In humans, there are 29 known family members of the TNF receptor superfamily. [6] [7] Historically, the family members have been numerically classified as TNFRSF#, where # denotes the member number, sometimes followed a letter. [2] Some newer additions to the TNF family remain unnumbered, however, such as the TNF receptor superfamily member ...
Tumor necrosis factor receptor superfamily member 12A also known as the TWEAK receptor (TWEAKR) is a protein that in humans is encoded by the TNFRSF12A gene. [ 5 ] [ 6 ] [ 7 ] Other names used when talking about TNFRSF12A are fibroblast growth factor-inducible immediate-early response protein 14 (FN14). [ 8 ]
GITR is a member of TNFR superfamily and shares high homology in cytoplasmic domain, characterized with cysteine pseudo-repeats, with other members of TNFRSF, such as CD137, OX40 or CD27. [ 8 ] GITR is constitutively expressed on CD25+ CD4 + regulatory T cells and its expression is upregulated on all T cell subsets after activation.
The protein encoded by this gene is a member of the tumor necrosis factor receptor superfamily, which also contains TNFRSF1A.This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity.
RANKL is a member of the tumor necrosis factor (TNF) cytokine family. It binds to RANK on cells of the myeloid lineage and functions as a key factor for osteoclast differentiation and activation. RANKL may also bind to osteoprotegerin , a protein secreted mainly by cells of the osteoblast lineage which is a potent inhibitor of osteoclast ...
21944 Ensembl ENSG00000239697 ENSMUSG00000097328 UniProt O43508 O54907 RefSeq (mRNA) NM_003809 NM_011614 RefSeq (protein) NP_003800 NP_035744 Location (UCSC) Chr 17: 7.55 – 7.56 Mb Chr 11: 69.58 – 69.59 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Tumor necrosis factor ligand superfamily member 12 also known as TNF-related weak inducer of apoptosis (TWEAK) is a protein that in ...