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N-Nitrosodimethylamine (NDMA), also known as dimethylnitrosamine (DMN), is an organic compound with the formula (CH 3) 2 NNO. It is one of the simplest members of a large class of nitrosamines. It is a volatile yellow oil. NDMA has attracted wide attention as being highly hepatotoxic and a known carcinogen in laboratory animals. [2]
Flow table with a grip and a hinge, 70 centimetres (28 in) square. In the American version of this test, the table is 10 inches (25 cm) diameter per ASTM C 230.; Abrams cone, open at the top and at the bottom - 30 centimetres (12 in) high, 17 centimetres (6.7 in) top diameter, 25 centimetres (9.8 in) base diameter.
In the 1980s, the European Union began harmonising regulatory requirements. In 1989, Europe, Japan, and the United States began creating plans for harmonisation. The International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH) was created in April 1990 at a meeting in Brussels.
[1] [2] The R groups can be any group, typically hydrogen (e.g., methylnitroamine CH 3 −NH−NO 2) and organyl (e.g., diethylnitroamine (CH 3 CH 2 −) 2 N−NO 2). An example of inorganic nitroamine is chloronitroamine, Cl−NH−NO 2. [3] The parent inorganic compound, where both R substituents are hydrogen, is nitramide or nitroamine, H 2 ...
Nitrosamides are chemical compounds that contain of the chemical structure R 1 C(=X)N(–R 2)–N=O, that is, a nitroso group bonded to the nitrogen of an amide or similar functional group. [1] Specific classes include the N -nitrosamides, N -nitroso ureas , N -nitroso guanidines , and N -nitroso carbamates .
The US EPA limits N-nitrosoglyphosate impurity to a maximum of 1 ppm in glyphosate formulated products. [1] N -Nitrosoglyphosate can also form from the reaction of nitrates and glyphosate. Formation of N -nitrosoglyphosate has been observed in soils treated with sodium nitrite and glyphosate at elevated levels, though formation in soil is not ...
With regards to structure, the C 2 N 2 O core of nitrosamines is planar, as established by X-ray crystallography. The N-N and N-O distances are 132 and 126 pm, respectively in dimethylnitrosamine , [ 13 ] one of the simplest members of a large class of N-nitrosamines
Section 1: Physical Chemical Properties; Section 2: Effects on Biotic Systems; Section 3: Environmental Fate and Behaviour; Section 4: Health Effects; Section 5: Other Test Guidelines; Guidelines are numbered with three digit numbers, the section number being the first number. Sometimes guidelines are suffixed with a letter.