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Irinotecan is a hydrophilic compound with a large volume of distribution (400 L/m 2). [20] [21] At physiological pH, irinotecan and its active metabolite ethyl-10-hydroxy-camptothecin (SN-38) are present in two pH-dependent equilibrium isoforms; the anti tumor active lactone ring which hydrolyzed to the carboxylate isoform. [21]
It is the active metabolite of irinotecan (an analog of camptothecin - a topoisomerase I inhibitor) but has 1000 times more activity than irinotecan itself. In vitro cytotoxicity assays show that the potency of SN-38 relative to irinotecan varies from 2- to 2000-fold.
Improving nutrition of female, both before and during pregnancy, is important for reducing the risk of obstructive labor. [11] Creating education programs about reproduction and increasing access to reproductive services such as contraception and family planning in developing areas can also reduce the prevalence of obstructed labor.
Postterm pregnancy, i.e. if the pregnancy has gone past the end of the 42nd week. Intrauterine fetal growth restriction. There are health risks to the woman in continuing the pregnancy (e.g. pre-eclampsia). Premature rupture of the membranes); this is when the membranes have ruptured, but labor does not start within a specific amount of time. [3]
Etirinotecan pegol (trade name Onzeald) is a drug developed by Nektar Therapeutics for the treatment of certain kinds of breast cancer with brain metastases.The European Medicines Agency refused to grant it a marketing authorisation in 2017.
Hamdard Laboratories produces more than six hundred (600) Herbal Products. [1]Hamdard has a full range of medicines for digestive disorders of stomach and intestine, abdominal cramps, hyper-acidity etc., anemia, jaundice, purification of blood from impurities, liver ailments, female ailments like leucorrhoea, menstrual irregularities and for protection of pregnancy.
A progestogen, also referred to as a progestagen, gestagen, or gestogen, is a type of medication which produces effects similar to those of the natural female sex hormone progesterone in the body. [1]
Obstetric ultrasonography, or prenatal ultrasound, is the use of medical ultrasonography in pregnancy, in which sound waves are used to create real-time visual images of the developing embryo or fetus in the uterus (womb).