Search results
Results from the WOW.Com Content Network
Knowing the difference between the sense and antisense strands is important in certain molecular biology applications. For example, in microarray expression technologies, it is important to know which strand is "viewed" on the array. An array can correspond to either strand; however, a single array will be made entirely of "sense" or "antisense ...
In molecular biology and genetics, the sense of a nucleic acid molecule, particularly of a strand of DNA or RNA, refers to the nature of the roles of the strand and its complement in specifying a sequence of amino acids.
By convention, the coding strand is the strand used when displaying a DNA sequence. It is presented in the 5' to 3' direction. Wherever a gene exists on a DNA molecule, one strand is the coding strand (or sense strand), and the other is the noncoding strand (also called the antisense strand, [3] anticoding strand, template strand or transcribed ...
The sense strand is, generally, the transcribed sequence of DNA or the RNA that was generated in transcription, while the anti-sense strand is the strand that is complementary to the sense sequence. Self-complementarity and hairpin loops
For example, in a typical gene a start codon (5′-ATG-3′) is a DNA sequence within the sense strand. Transcription begins at an upstream site (relative to the sense strand), and as it proceeds through the region it copies the 3′-TAC-5′ from the template strand to produce 5′-AUG-3′ within a messenger RNA (mRNA).
This 'sense' or 'coding' strand, runs in the 5' to 3' direction where the numbers refer to the carbon atoms of the backbone's ribose sugar. The open reading frame (ORF) of a gene is therefore usually represented as an arrow indicating the direction in which the sense strand is read. [7] Regulatory sequences are located at the extremities of genes.
In molecular biology and genetics, upstream and downstream both refer to relative positions of genetic code in DNA or RNA.Each strand of DNA or RNA has a 5' end and a 3' end, so named for the carbon position on the deoxyribose (or ribose) ring.
As the two strands of a double-stranded nucleic acid molecule are antiparallel, the 5′→3′ direction on the second strand corresponds to the 3′→5′ direction along the first strand. [1] [2] In general, at the most, one reading frame in a given section of a nucleic acid, is biologically relevant (open reading frame). Some viral ...