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107221 Ensembl ENSG00000186188 ENSMUSG00000054200 UniProt Q5NUL3 Q7TMA4 RefSeq (mRNA) NM_001195755 NM_181745 NM_181748 RefSeq (protein) NP_001182684 NP_859529 NP_861413 Location (UCSC) Chr 10: 93.57 – 93.6 Mb Chr 19: 38.09 – 38.1 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Free Fatty acid receptor 4 (FFAR4), also termed G-protein coupled receptor 120 (GPR120), is a protein ...
ITAMs are important for signal transduction, mainly in immune cells. They are found in the cytoplasmic tails of non-catalytic tyrosine-phosphorylated receptors [7] such as the CD3 and ζ-chains of the T cell receptor complex, the CD79-alpha and -beta chains of the B cell receptor complex, and certain Fc receptors.
The epidermal growth factor receptor is a member of the ErbB family of receptors, a subfamily of four closely related receptor tyrosine kinases: EGFR (ErbB-1), HER2/neu (ErbB-2), Her 3 (ErbB-3) and Her 4 (ErbB-4). In many cancer types, mutations affecting EGFR expression or activity could result in cancer. [6]
While CXCR4's expression is low or absent in many healthy tissues, it was demonstrated to be expressed in over 23 types of cancer, including breast cancer, ovarian cancer, melanoma, and prostate cancer. Expression of this receptor in cancer cells has been linked to metastasis to tissues containing a high concentration of CXCL12, such as lungs ...
GPR84 binds and is activated by medium-chain fatty acids consisting of 9 to 14 carbon atoms such as capric, undecaenoic, and lauric acids. [21] [22] It has been recognized as a possible member of the free fatty acid receptor family in some publications [23] but has not yet been given this designation perhaps because these medium-chain fatty acid activators require very high concentrations (e.g ...
The estrogen receptor test (ERT) is a laboratory test to determine whether cancer cells have estrogen receptors.This information can guide treatment of the cancer. [1]The test uses immunohistochemical techniques on the estrogen receptor (ER).
The receptor is normally triggered via direct cell-to-cell contact, in which the transmembrane proteins of the cells in direct contact form the ligands that bind the notch receptor. The Notch binding allows groups of cells to organize themselves such that, if one cell expresses a given trait, this may be switched off in neighbouring cells by ...
Amplification of FGFR1 also occurs in ~10% of estrogen receptor positive breast cancers, particularly of the luminal subtype B form of breast cancer. The presence of FGFR1 amplification has been correlated with resistance to hormone blocking therapy and found to be a poor prognostic factor in the disease. [9] [10]