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Fibrinogen (coagulation factor I) is a glycoprotein complex, produced in the liver, [1] that circulates in the blood of all vertebrates. [2] During tissue and vascular injury, it is converted enzymatically by thrombin to fibrin and then to a fibrin-based blood clot. Fibrin clots function primarily to occlude blood vessels to stop bleeding ...
Fibrinogen beta chain, also known as FGB, is a gene found in humans and most other vertebrates with a similar system of blood coagulation. The protein encoded by this gene is the beta component of fibrinogen , a blood-borne glycoprotein composed of three pairs of nonidentical polypeptide chains.
Digestive function, bilirubin excretion 2-30 × 10 −6: 3-30 × 10 −6: Bilirubin: Hemoglobin metabolite 2-14 × 10 −6: 1-10 × 10 −6: Biotin (Vitamin H) Gluconeogenesis, metabolize leucine, fatty acid synthesis 7-17 × 10 −9: 9-16 × 10 −9: Blood Urea Nitrogen (BUN) 8-23 × 10 −5: Bradykinin: 7 × 10 −11: Bromide: 7-10 × 10 −9 ...
2243 14161 Ensembl ENSG00000171560 ENSMUSG00000028001 UniProt P02671 E9PV24 RefSeq (mRNA) NM_000508 NM_021871 NM_001111048 NM_010196 RefSeq (protein) NP_000499 NP_068657 NP_001104518 NP_034326 Location (UCSC) Chr 4: 154.58 – 154.59 Mb Chr 3: 82.93 – 82.94 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Fibrinogen alpha chain is a protein that in humans is encoded by the FGA gene ...
Fibrin is formed after thrombin cleavage of fibrinopeptide A (FPA) from fibrinogen Aalpha-chains, thus initiating fibrin polymerization. Double-stranded fibrils form through end-to-middle domain (D:E) associations, and concomitant lateral fibril associations and branching create a clot network.
Globulins make up 38% of blood proteins and transport ions, hormones, and lipids assisting in immune function. Fibrinogen comprises 7% of blood proteins; conversion of fibrinogen to insoluble fibrin is essential for blood clotting. The remainder of the plasma proteins (1%) are regulatory proteins, such as enzymes, proenzymes, and hormones.
2266 99571 Ensembl ENSG00000171557 ENSMUSG00000033860 UniProt P02679 Q8VCM7 RefSeq (mRNA) NM_021870 NM_000509 NM_133862 NM_001317105 RefSeq (protein) NP_000500 NP_068656 NP_001304034 NP_598623 Location (UCSC) Chr 4: 154.6 – 154.61 Mb Chr 3: 82.92 – 82.92 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Fibrinogen gamma chain, also known as fibrinogen gamma gene (FGG), is a human ...
Hereditary fibrinogen Aα-Chain amyloidosis is a sub-category of congenital dysfibrinogenemia in which the dysfunctional fibrinogen does not cause bleeding or thrombosis but rather gradually accumulates in, and disrupts the function of, the kidney. [6] Congenital dysfibrinogenemia is the commonest of these three disorders.
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