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  2. Staining - Wikipedia

    en.wikipedia.org/wiki/Staining

    Unlike negative staining, positive staining uses basic dyes to color the specimen against a bright background. While chromophore is used for both negative and positive staining alike, the type of chromophore used in this technique is a positively charged ion instead of a negative one. The negatively charged cell wall of many microorganisms ...

  3. Gram-positive bacteria - Wikipedia

    en.wikipedia.org/wiki/Gram-positive_bacteria

    Both gram-positive and gram-negative bacteria commonly have a surface layer called an S-layer. In gram-positive bacteria, the S-layer is attached to the peptidoglycan layer. Gram-negative bacteria's S-layer is attached directly to the outer membrane. Specific to gram-positive bacteria is the presence of teichoic acids in the cell wall. Some of ...

  4. Gram stain - Wikipedia

    en.wikipedia.org/wiki/Gram_stain

    Gram stain (Gram staining or Gram's method), is a method of staining used to classify bacterial species into two large groups: gram-positive bacteria and gram-negative bacteria. It may also be used to diagnose a fungal infection. [1] The name comes from the Danish bacteriologist Hans Christian Gram, who developed the technique in 1884. [2]

  5. Immunostaining - Wikipedia

    en.wikipedia.org/wiki/Immunostaining

    The term "immunostaining" was originally used to refer to the immunohistochemical staining of tissue sections, as first described by Albert Coons in 1941. [1] However, immunostaining now encompasses a broad range of techniques used in histology, cell biology, and molecular biology that use antibody-based staining methods.

  6. Periodic acid–Schiff stain - Wikipedia

    en.wikipedia.org/wiki/Periodic_acid–Schiff_stain

    Staining macrophages in Whipple's disease. [3] It can be used to diagnose α1-antitrypsin deficiency if periportal liver hepatocytes stain positive. Aggregates of PAS-positive lymphocytes are present in epidermis in Mycosis fungoides and Sézary syndrome, called Pautrier microabscesses. Ewing sarcoma; Erythroleukemia, a leukemia of immature red ...

  7. Basophilic - Wikipedia

    en.wikipedia.org/wiki/Basophilic

    Main staining types when using hematoxylin and eosin (H&E). A Basophil granulocyte stains dark purple upon H&E staining. Basophilic is a technical term used by pathologists. It describes the appearance of cells, tissues and cellular structures as seen through the microscope after a histological section has been stained with a basic dye.

  8. Acid-fastness - Wikipedia

    en.wikipedia.org/wiki/Acid-fastness

    Fungal yeast forms are inconsistently stained with Acid-fast stain which is considered a narrow spectrum stain for fungi. [21] In a study on acid-fastness of fungi, [ 22 ] 60% of blastomyces and 47% of histoplasma showed positive cytoplasmic staining of the yeast-like cells, and Cryptococcus or candida did not stain, and very rare staining was ...

  9. Immunofluorescence - Wikipedia

    en.wikipedia.org/wiki/Immunofluorescence

    Immunofluorescence is a widely used example of immunostaining (using antibodies to stain proteins) and is a specific example of immunohistochemistry (the use of the antibody-antigen relationship in tissues). This technique primarily utilizes fluorophores to visualize the location of the antibodies, while others provoke a color change in the ...