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  2. Ranitidine - Wikipedia

    en.wikipedia.org/wiki/Ranitidine

    Ranitidine has 10% of the affinity that cimetidine has to CYP450, so it causes fewer side effects, but other H 2 blockers famotidine and nizatidine have no CYP450 significant interactions. [131] Ranitidine was introduced in 1981, and was the world's biggest-selling prescription drug by 1987. [132]

  3. Delaware judge lets more than 70,000 Zantac lawsuits go forward

    www.aol.com/news/delaware-judge-lets-more-70...

    (Reuters) -A Delaware judge has allowed more than 70,000 lawsuits over discontinued heartburn drug Zantac to go forward, ruling that expert witnesses can testify in court that the drug may cause ...

  4. GSK asks to appeal Delaware ruling allowing Zantac cases to ...

    www.aol.com/news/latest-trial-over-zantac-cancer...

    First approved in 1983, Zantac became the world's best-selling medicine in 1988 and one of the first to top $1 billion in annual sales. It was originally marketed by a forerunner of GSK and later ...

  5. GSK settles two California lawsuits related to heartburn drug ...

    www.aol.com/news/gsk-settles-two-california...

    The drugmaker has settled a series of lawsuits related to Zantac over the past 12 months, including several in California. California is generally seen as a more challenging legal environment for ...

  6. Famotidine - Wikipedia

    en.wikipedia.org/wiki/Famotidine

    Common side effects include headache, abdominal pain, diarrhea or constipation, and dizziness. [4] Serious side effects may include pneumonia and seizures. [4] [5] Use in pregnancy appears safe but has not been well studied, while use during breastfeeding is not recommended. [1] Famotidine was patented in 1979 and came into medical use in 1985. [6]

  7. GSK settles another California lawsuit on heartburn drug Zantac

    www.aol.com/news/drugmaker-gsk-settles...

    GSK on Wednesday said it agreed to settle another lawsuit in California alleging its discontinued heartburn drug Zantac caused cancer, as the British drugmaker sought to end costly litigation that ...

  8. H2 receptor antagonist - Wikipedia

    en.wikipedia.org/wiki/H2_receptor_antagonist

    Cimetidine was the prototypical histamine H 2 receptor antagonist from which later drugs were developed. Cimetidine was the culmination of a project at Smith, Kline & French (SK&F; now GlaxoSmithKline) by James W. Black, C. Robin Ganellin, and others to develop a histamine receptor antagonist that would suppress stomach acid secretion.

  9. GSK settles another Zantac lawsuit in California - AOL

    www.aol.com/news/gsk-confidentially-settles...

    In 2019, some manufacturers and pharmacies halted Zantac sales over concerns that its active ingredient, ranitidine, degraded over time to form a chemical called NDMA. While NDMA can be present in ...

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