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Paneth cells are found throughout the small intestine and the appendix at the base of the intestinal glands. [2] There is an increase in Paneth cell numbers towards the end of the small intestine. [3] Like the other epithelial cell lineages in the small intestine, Paneth cells originate at the stem cell region near the bottom of the gland. [4]
Involves in epithelial cell maturation as well as goblet and Paneth cell differentiation. Required for the small intestinal identity during development. In IEC-6 cells, conditional expression induced enterocyte and goblet like cells: 21081128 [13] 19386267 [14] 8552090 [15] CTNNB1: Catenin, beta: Paneth cell differentiation.
Paneth cells produce antimicrobial peptides such as human alpha-defensin. [11] [12] Microfold cells (commonly referred to as M cells) sample antigens from the lumen and deliver them to the lymphoid tissue associated with the mucosa (MALT). In the small intestine, M cells are associated with Peyer's patches. Cup cells are a distinct cell type ...
Intestinal glands are found in the epithelia of the small intestine, namely the duodenum, jejunum, and ileum, and in the large intestine (colon), where they are sometimes called colonic crypts. Intestinal glands of the small intestine contain a base of replicating stem cells , Paneth cells of the innate immune system , and goblet cells , which ...
Merocrine secretion Paneth cells, located at the base of the crypts of the small intestinal mucosa, and displaying merocrine secretion of bright red cytoplasmic granules. H&E stain. Merocrine (or eccrine) is a term used to classify exocrine glands and their secretions in the study of histology.
Paneth cells: small intestine: serous 28 Gley's glands, Sandstroem's glands, parathyroid gland: in the neck parathyroid hormone: 29 Parietal cell: stomach: hydrochloric acid, intrinsic factor: dynamic canaliculi 30 Parotid gland: mouth: saliva tubulo-alveolar 31 Peyer's patches (or glands) ileum, lymphatic glands Pineal gland: brain: melatonin ...
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Alpha-defensins, which have been identified in humans, monkeys and several rodent species, are particularly abundant in neutrophils, certain macrophage populations and Paneth cells of the small intestine. Defensins are produced constitutively and/or in response to microbial products or proinflammatory cytokines.