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  2. Postoperative cognitive dysfunction - Wikipedia

    en.wikipedia.org/wiki/Postoperative_cognitive...

    The body's inflammatory response to surgery likely plays an important role, at least in elderly patients. Various research initiatives during recent years have evaluated whether actions taken before, during and after surgery can lessen the possible deleterious effects of inflammation. For example, anti-inflammatory agents can be given before ...

  3. Limbic-predominant age-related TDP-43 encephalopathy

    en.wikipedia.org/wiki/Limbic-predominant_age...

    The hallmark symptom of LATE is a progressive memory loss that predominantly affects short-term and episodic memory. [1] This impairment is often severe enough to interfere with daily functioning and usually remains the chief neurologic deficit, unlike other types of dementia in which non-memory cognitive domains and behavioral changes might be noted earlier or more prominently. [1]

  4. Early-onset Alzheimer's disease - Wikipedia

    en.wikipedia.org/wiki/Early-onset_Alzheimer's...

    Alzheimer's disease (AD) is a neurodegenerative disease and the most common cause of dementia; it usually occurs in old age. Familial Alzheimer's disease (FAD or EOFAD for early onset) is an inherited and uncommon form of AD. Familial AD usually strikes earlier in life, defined as before the age of 65.

  5. Midodrine - Wikipedia

    en.wikipedia.org/wiki/Midodrine

    Midodrine is a prodrug of its active metabolite desglymidodrine. [3] [1] This metabolite acts as a selective agonist of the α 1-adrenergic receptor. [3] [1] This in turn results in vasoconstriction and increased blood pressure. [3] [1] Midodrine was discovered by 1971 [6] and was introduced for medical use in the United States in 1996 ...

  6. Early onset dementia - Wikipedia

    en.wikipedia.org/wiki/Early_onset_dementia

    The term young onset dementia is becoming more widely used to avoid the potential confusion between early onset dementia and early stage dementia. This term is now used as presenile dementia which is a historical term of people diagnosed with dementia from a younger age of 51 years old. This is caused by an atypical arterioclerosis of the brain.

  7. Postperfusion syndrome - Wikipedia

    en.wikipedia.org/wiki/Postperfusion_syndrome

    Postperfusion syndrome, also known as "pumphead", is a constellation of neurocognitive impairments attributed to cardiopulmonary bypass (CPB) during cardiac surgery. Symptoms of postperfusion syndrome are subtle and include defects associated with attention, concentration, short-term memory, fine motor function, and speed of mental and motor ...

  8. Desglymidodrine - Wikipedia

    en.wikipedia.org/wiki/Desglymidodrine

    Desglymidodrine (developmental code name ST-1059) is the active metabolite of the prodrug antihypotensive agent midodrine. [1] [2] [3] It acts as a selective α 1-adrenergic receptor agonist. [1] [2] [3] Desglymidodrine is formed from midodrine via deglycination. [1] [2] [3]

  9. Cerebral amyloid angiopathy - Wikipedia

    en.wikipedia.org/wiki/Cerebral_amyloid_angiopathy

    CAA is associated with brain hemorrhages, particularly microhemorrhages.The accumulation of amyloid beta peptide deposits in the blood vessel walls results in damage of the blood vessels and hindrance of normal blood flow, making blood vessels more prone to bleeding [10] Since CAA can be caused by the same amyloid protein that is associated with Alzheimer's dementia, brain bleeds [11] are more ...

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