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2. Phosphofructokinase 1 - Wikipedia

   en.wikipedia.org/wiki/Phosphofructokinase_1

   Phosphofructokinase-1 (PFK-1) is one of the most important regulatory enzymes (EC 2.7.1.11) of glycolysis. It is an allosteric enzyme made of 4 subunits and controlled by many activators and inhibitors. PFK-1 catalyzes the important "committed" step of glycolysis, the conversion of fructose 6-phosphate and ATP to fructose 1,6-bisphosphate and ...

3. Phosphofructokinase 2 - Wikipedia

   en.wikipedia.org/wiki/Phosphofructokinase_2

   PFK-2 is known as the "bifunctional enzyme" because of its notable structure: though both are located on one protein homodimer, its two domains act as independently functioning enzymes. [5] One terminus serves as a kinase domain (for PFK-2) while the other terminus acts as a phosphatase domain (FBPase-2). [6]

4. Phosphofructokinase - Wikipedia

   en.wikipedia.org/wiki/Phosphofructokinase

   PFK exists as a homotetramer in bacteria and mammals (where each monomer possesses 2 similar domains) and as an octomer in yeast (where there are 4 alpha- (PFK1) and 4 beta-chains (PFK2), the latter, like the mammalian monomers, possessing 2 similar domains [3]). This protein may use the morpheein model of allosteric regulation. [5]

5. PFKP - Wikipedia

   en.wikipedia.org/wiki/PFKP

   The PFKP gene encodes the platelet isoform of phosphofructokinase (PFK) (ATP:D-fructose-6-phosphate-1-phosphotransferase, EC 2.7.1.11). PFK catalyzes the irreversible conversion of fructose 6-phosphate to fructose 1,6-bisphosphate and is a key regulatory enzyme in glycolysis. The PFKP gene, which maps to chromosome 10p, is also expressed in ...

6. Glucose-1,6-bisphosphate synthase - Wikipedia

   en.wikipedia.org/wiki/Glucose-1,6-bisphosphate...

   The main product, glucose-1,6-bisphosphate, appears to have several functions: 1. Inhibition of hexokinase, an enzyme used in the first step of glycolysis. [2] 2. Activation of phosphofructokinase-1 (PFK-1) and pyruvate kinase, both of which are enzymes involved in activation of the glycolytic pathway. [2] [3] 3.

7. PFKM - Wikipedia

   en.wikipedia.org/wiki/PFKM

   This 85-kDa protein is one of two subunit types that comprise the seven tetrameric PFK isozymes. [6] [7] The muscle isozyme is composed solely of PFKM.[6] [8] [9] The liver PFK (PFK-5) contains solely the second subunit type, PFKL, while the erythrocyte PFK includes five isozymes composed of different combinations of PFKM and PFKL.

8. Fructose 2,6-bisphosphate - Wikipedia

   en.wikipedia.org/wiki/Fructose_2,6-bisphosphate

   Fru-2,6-P 2 strongly activates glucose breakdown in glycolysis through allosteric modulation (activation) of phosphofructokinase 1 (PFK-1).Elevated expression of Fru-2,6-P 2 levels in the liver allosterically activates phosphofructokinase 1 by increasing the enzyme’s affinity for fructose 6-phosphate, while decreasing its affinity for inhibitory ATP and citrate.

9. 1-phosphofructokinase - Wikipedia

   en.wikipedia.org/wiki/1-phosphofructokinase

   In enzymology, 1-phosphofructokinase (EC 2.7.1.56) is an enzyme that catalyzes the chemical reaction. ATP + D-fructose 1-phosphate → ADP + D-fructose 1,6-bisphosphate. Thus, the two substrates of this enzyme are ATP and D-fructose 1-phosphate, whereas its two products are ADP and D-fructose 1,6-bisphosphate. The enzyme was first described and ...