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In molecular biology, enzymes in the DNA/RNA non-specific endonuclease family of bacterial and eukaryotic endonucleases EC 3.1.30.-share the following characteristics: they act on both DNA and RNA, cleave double-stranded and single-stranded nucleic acids and require a divalent ion such as magnesium for their activity.
ERCC4 is a protein designated as DNA repair endonuclease XPF that in humans is encoded by the ERCC4 gene. Together with ERCC1, ERCC4 forms the ERCC1-XPF enzyme complex that participates in DNA repair and DNA recombination. [5] [6] The nuclease enzyme ERCC1-XPF cuts specific structures of DNA. Many aspects of these two gene products are ...
The ERCC1–XPF complex is a structure-specific endonuclease. ERCC1-XPF does not cut DNA that is exclusively single-stranded or double-stranded, but it cleaves the DNA phosphodiester backbone specifically at junctions between double-stranded and single-stranded DNA.
A deficiency in ERCC1 and/or ERCC4 (XPF) would cause DNA damage accumulation. Such excess DNA damage often leads to apoptosis. [32] However, an added defect in PMS2 can inhibit this apoptosis. [33] [34] Thus, an added deficiency in PMS2 likely would be selected for in the face of the increased DNA damages when ERCC1 and/or ERCC4 (XPF) are ...
Deficiency of ERCC4(XPF) in humans results in a variety of conditions including accelerated aging. [ 23 ] In humans, mutational defects in the ERCC5 (XPG) gene can cause either the cancer-prone condition xeroderma pigmentosum (XP) alone, or in combination with the severe neurodevelopmental disorder Cockayne syndrome (CS) or the infantile lethal ...
Ribonuclease H (abbreviated RNase H or RNH) is a family of non-sequence-specific endonuclease enzymes that catalyze the cleavage of RNA in an RNA/DNA substrate via a hydrolytic mechanism. Members of the RNase H family can be found in nearly all organisms, from bacteria to archaea to eukaryotes.
Evidence suggests that endonuclease activity experiences a lag compared to exonuclease activity. [2] Restriction enzymes are endonucleases from eubacteria and archaea that recognize a specific DNA sequence. [3] The nucleotide sequence recognized for cleavage by a restriction enzyme is called the restriction site.
2073 22592 Ensembl ENSG00000134899 ENSMUSG00000026048 UniProt P28715 P35689 RefSeq (mRNA) NM_000123 NM_011729 RefSeq (protein) NP_000114 n/a Location (UCSC) Chr 13: 102.85 – 102.88 Mb Chr 1: 44.19 – 44.22 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse DNA repair protein complementing XP-G cells is a protein that in humans is encoded by the ERCC5 gene. Function Excision repair ...