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Group exposed to a risk factor (left) has increased risk of an adverse outcome (black) compared to the unexposed group (right). 4 individuals need to be exposed for 1 adverse outcome to occur (NNH = 4). In medicine, the number needed to harm (NNH) is an epidemiological measure that indicates how many persons on average need to be exposed to a ...
The number needed to treat (NNT) or number needed to treat for an additional beneficial outcome (NNTB) is an epidemiological measure used in communicating the effectiveness of a health-care intervention, typically a treatment with medication.
The adverse outcome (black) risk difference between the group exposed to the treatment (left) and the group unexposed to the treatment (right) is −0.25 (RD = −0.25, ARR = 0.25).
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The PDF of the essay paper "Why Most Published Research Findings Are False" is a 2005 essay written by John Ioannidis, a professor at the Stanford School of Medicine, and published in PLOS Medicine. [1] It is considered foundational to the field of metascience.
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Description: The Heart Protection Study is a large randomized controlled trial by the Medical Research Council (MRC) in the United Kingdom. It studies the use of statin ( simvastatin 40 mg) medication and vitamin supplementation ( vitamin E , vitamin C and beta carotene ) in patients that are at risk for cardiovascular disease .
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