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Treponema denticola is a Gram-negative, obligate anaerobic, motile and highly proteolytic spirochete bacterium. It is one of four species of oral spirochetes to be reliably cultured, the others being Treponema pectinovorum, Treponema socranskii and Treponema vincentii [ 2 ] .
Chronic periodontitis is initiated by Gram-negative tooth-associated microbial biofilms that elicit a host response, which results in bone and soft tissue destruction. In response to endotoxin derived from periodontal pathogens, several osteoclast-related mediators target the destruction of alveolar bone and supporting connective tissue such as the periodontal ligament.
It is the second largest of the human body and made of various bacteria, viruses, fungi and protozoa. [14] These organisms play an important role in oral and overall health. Anthony Van Leeuwenhoek was the first to view these organisms using a microscope he created. [ 14 ]
Periodontal disease typically arises from the development of plaque biofilm, which harbors harmful bacteria such as Porphyromonas gingivalis and Treponema denticola. These bacteria infect the gum tissue surrounding the teeth, leading to inflammation and, if left untreated, progressive damage to the teeth and gum tissue. [9]
If improperly treated necrotizing may become chronic and/or recurrent. In developed countries, necrotizing gingivitis occurs mostly in young adults with predisposing factors such as psychological stress, sleep deprivation, poor oral hygiene, smoking, immunosuppression and/or malnutrition. In developing countries, necrotizing gingivitis occurs ...
Secondary features are characteristics which are frequently seen but not always present in every patient diagnosed with aggressive periodontitis. The severity of periodontal tissue destruction is out of proportion to amount of bacteria present. [19] The amount of bacteria is often indicated by the level of dental plaque. [27]
Foreign body reactions appear as red or red and white, possibly painful longstanding lesions similar to desquamative gingivitis, or be granulomatous or lichenoid in nature. Tiny particles of dental materials (e.g. abrasive polishing pastes) may become impregnated in the gingival tissues and trigger a chronic inflammatory cell response. [5]
Main article: Human parasite Endoparasites Protozoan organisms Common name of organism or disease Latin name (sorted) Body parts affected Diagnostic specimen Prevalence Source/Transmission (Reservoir/Vector) Granulomatous amoebic encephalitis and Acanthamoeba keratitis (eye infection) Acanthamoeba spp. eye, brain, skin culture worldwide contact lenses cleaned with contaminated tap water ...