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Trypsin is an enzyme in the first section of the small intestine that starts the digestion of protein molecules by cutting long chains of amino acids into smaller pieces. It is a serine protease from the PA clan superfamily, found in the digestive system of many vertebrates, where it hydrolyzes proteins.
Trypsinogen (/ ˌ t r ɪ p ˈ s ɪ n ə dʒ ə n,-ˌ dʒ ɛ n / [1] [2]) is the precursor form (or zymogen) of trypsin, a digestive enzyme.It is produced by the pancreas and found in pancreatic juice, along with amylase, lipase, and chymotrypsinogen.
Enteropeptidase (also called enterokinase) is an enzyme produced by cells of the duodenum and is involved in digestion in humans and other animals. Enteropeptidase converts trypsinogen (a zymogen) into its active form trypsin, resulting in the subsequent activation of pancreatic digestive enzymes.
As a result, the zymogen trypsinogen breaks down into trypsin. Recall that trypsin is also responsible for cleaving lysine peptide bonds, and thus, once a small amount of trypsin is generated, it participates in cleavage of its own zymogen, generating even more trypsin. The process of trypsin activation can thus be called autocatalytic.
Trypsinogen is activated via the duodenal enzyme enterokinase into its active form trypsin. Chymotrypsinogen, which is an inactive (zymogenic) protease that, once activated by duodenal enterokinase, turns into chymotrypsin and breaks down proteins at their aromatic amino acids. Chymotrypsinogen can also be activated by trypsin.
Pancreatic juice is a liquid secreted by the pancreas, [1] which contains a number of digestive enzymes, including trypsinogen, chymotrypsinogen, elastase, carboxypeptidase, pancreatic lipase, nucleases and amylase.
On Feb. 7, 2022, baby Soren was born — surprising doctors and medical staff by breathing on his own without the help of oxygen. "Besides his heart, he was a perfectly healthy baby boy," Morgan says.
436522 Ensembl ENSG00000274247 ENSG00000204983 ENSMUSG00000071521 UniProt P07477 Q792Z1 RefSeq (mRNA) NM_002769 NM_001038996 RefSeq (protein) NP_002760 NP_001034085 Location (UCSC) Chr 7: 142.75 – 142.75 Mb Chr 6: 41.33 – 41.33 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Trypsin-1, also known as cationic trypsinogen, is a protein that in humans is encoded by the PRSS1 gene ...