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CML is more common in males than in females (male to female ratio of 1.4:1) and appears more commonly in the elderly with a median age at diagnosis of 65 years. [5] Exposure to ionising radiation appears to be a risk factor, based on a 50 fold higher incidence of CML in Hiroshima and Nagasaki nuclear bombing survivors. [ 5 ]
Specialty: Hematology and oncology: Symptoms: Bleeding, bruising, fatigue, fever, increased risk of infections [2] Usual onset: All ages, [3] most common in 60s and 70s. [4] It is the most common malignant cancer in children, but the cure rates are also higher for them.
In adults, blood cells are formed in the bone marrow, by a process that is known as haematopoiesis. In CMML, there are increased numbers of monocytes and immature blood cells ( blasts ) in the peripheral blood and bone marrow, as well as abnormal looking cells ( dysplasia ) in at least one type of blood cell.
The prognosis depends on the type of cells affected, the number of blasts in the bone marrow or blood, and the changes present in the chromosomes of the affected cells. [3] The average survival time following diagnosis is 2.5 years. [4] MDS was first recognized in the early 1900s; [5] it came to be called myelodysplastic syndrome in 1976. [5]
Accelerated phase chronic myelogenous leukemia is a phase of chronic myelogenous leukemia in which the disease ... Common symptoms include fever, bone pain, and ...
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Chronic phase chronic myelogenous leukemia is a phase of chronic myelogenous leukemia in which 5% or fewer of the cells in the blood and bone marrow are blast cells (immature blood cells). This phase may last from several months to several years, and there may be no symptoms of leukemia .
CLL is primarily a disease of older adults, with 9 out of 10 cases occurring after the age of 50 years. [89] The median age of diagnosis is 70 years. [89] In young people, new cases of CLL are twice as likely to be diagnosed in men than in women. [90]