Search results
Results from the WOW.Com Content Network
Working in the 19th century, biochemists initially isolated DNA and RNA (mixed together) from cell nuclei. They were relatively quick to appreciate the polymeric nature of their "nucleic acid" isolates, but realized only later that nucleotides were of two types—one containing ribose and the other deoxyribose. It was this subsequent discovery ...
In 1960, Jacob and collaborators discovered the operon which consists of a sequence of genes whose expression is coordinated by operator DNA. [30] In the period 1961 – 1967, through work in several different labs, the nature of the genetic code was determined (e.g. [31]).
1969: Molecular hybridization of radioactive DNA to the DNA of cytological preparation by Pardue, M. L. and Gall, J. G. 1970: Restriction enzymes were discovered in studies of a bacterium, Haemophilus influenzae, by Hamilton O. Smith and Daniel Nathans, enabling scientists to cut and paste DNA. [44]
Genomic DNA is tightly and orderly packed in the process called DNA condensation, to fit the small available volumes of the cell. In eukaryotes, DNA is located in the cell nucleus, with small amounts in mitochondria and chloroplasts. In prokaryotes, the DNA is held within an irregularly shaped body in the cytoplasm called the nucleoid. [97]
Short biography and bibliography in the Virtual Laboratory of the Max Planck Institute for the History of Science; FMI – Friedrich Miescher Institute; The Friedrich Miescher Laboratory of the Max Planck Society; Lasker Foundation; FMI – DNA Pioneers and Their Legacy by Ulf Lagerkvist; Dahm, Ralf (July–August 2008). "The First Discovery of ...
DNA ligases, that join broken DNA together, had been discovered earlier in 1967 [20] and by combining the two enzymes it was possible to "cut and paste" DNA sequences to create recombinant DNA. Plasmids, discovered in 1952, [21] became important tools for transferring information between cells and replicating DNA sequences. Frederick Sanger ...
The lack of 32 P-labeled DNA remaining in the solution after the bacteriophages had been allowed to adsorb to the bacteria showed that the phage DNA was transferred into the bacterial cell. The presence of almost all the radioactive 35 S in the solution showed that the protein coat that protects the DNA before adsorption stayed outside the cell ...
The discovery of DNA as the blueprint for life and breakthroughs in molecular genetics research came from the combined works of many scientists. In 1869, chemist Johann Friedrich Miescher, who was researching the composition of white blood cells, discovered and isolated a new molecule that he named nuclein from the cell nucleus, which would ultimately be the first discovery of the molecule DNA ...