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The vitamin D receptor (VDR also known as the calcitriol receptor) is a member of the nuclear receptor family of transcription factors. [5] Calcitriol (the active form of vitamin D , 1,25-(OH) 2 vitamin D 3 ) binds to VDR, which then forms a heterodimer with the retinoid-X receptor .
The VDR is widely distributed in tissues, and is not restricted to those tissues considered the classic targets of vitamin D. The VDR upon binding to 1,25(OH) 2 D heterodimerizes with other nuclear hormone receptors, in particular the family of retinoid X receptors. This VDR/RXR heterodimer complex binds to the specific VDRE in the promoters of ...
As an adjuvant to allograft bone or as a replacement for harvested autograft, bone morphogenetic proteins (BMPs) appear to improve fusion rates after spinal arthrodesis in both animal models and humans, while reducing the donor-site morbidity previously associated with such procedures. [19]
Skeletal muscle, smooth muscle, bone (osteoblasts), ventricular myocytes** (responsible for prolonged action potential in cardiac cell; also termed DHP receptors), dendrites and dendritic spines of cortical neurones P-type calcium channel ("Purkinje") /Q-type calcium channel: HVA (high voltage activated) Ca v 2.1 : α 2 δ, β, possibly γ
From a paper by Oscar Arias-Carrión, 2008 In an embryonic rat brain, GAD67-binding marker tends to concentrate in subventricular zone. An image from Popp et al., 2009. [1] The subventricular zone (SVZ) is a region situated on the outside wall of each lateral ventricle of the vertebrate brain. [2] It is present in both the embryonic and adult ...
In a situation of lowered blood volume, secretion of renin by the kidneys results in the production of angiotensin II, which stimulates receptors in the VOLT and subfornical organ to complete a positive feedback loop. [9] [12] [13] These neurons also project to the median preoptic nucleus which is involved in controlling thirst. [11] [9] [12]
The human brain is the central organ of the nervous system, and with the spinal cord, comprises the central nervous system. It consists of the cerebrum, the brainstem and the cerebellum. The brain controls most of the activities of the body, processing, integrating, and coordinating the information it receives from the sensory nervous system ...
The area is located near the boundary between the temporal lobe and the insula, another important brain region involved in sensory processing and emotional responses. In terms of brain structure, Brodmann area 52 is bordered on the outside by another area called the anterior transverse temporal area 42 (H), which is involved in hearing.