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The inflection point at which the increase in response with increasing ligand concentration begins to slow is the EC 50, which can be mathematically determined by derivation of the best-fit line. While relying on a graph for estimation is more convenient, this typical method yields less accurate and precise results.
The parameters of the dose response curve reflect measures of potency (such as EC50, IC50, ED50, etc.) and measures of efficacy (such as tissue, cell or population response). A commonly used dose–response curve is the EC 50 curve, the half maximal effective concentration, where the EC 50 point is defined as the inflection point of the curve.
EC50 is incorporated in the Hill's Equation, a function that demonstrates the relationship between agonist concentration and ligand binding. EC50 is mathematically given as the inflection point of the equation.
In contrast to this article's previous definition of the Hill equation, the IUPHAR defines the Hill equation in terms of the tissue response (), as [1] = [] + [] = + ([]) where [] is the drug concentration, is the Hill coefficient, and is the drug concentration that produces a 50% maximal response.
In pharmacology, an effective dose (ED) or effective concentration (EC) is the dose or concentration of a drug that produces a biological response. [1] [2] The term "effective dose" is used when measurements are taken in vivo, while "effective concentration" is used when the measurements are taken in vitro.
A ligand binding assay (LBA) is an assay, or an analytic procedure, which relies on the binding of ligand molecules to receptors, antibodies or other macromolecules. [1] A detection method is used to determine the presence and amount of the ligand-receptor complexes formed, and this is usually determined electrochemically or through a fluorescence detection method. [2]
Dalio is not the only one to point out the connection between U.S. politics and fiscal health. Moody's Investors Service recently changed its ratings outlook for the U.S. from "stable" to ...
A rising point of inflection is a point where the derivative is positive on both sides of the point; in other words, it is an inflection point near which the function is increasing. For a smooth curve given by parametric equations , a point is an inflection point if its signed curvature changes from plus to minus or from minus to plus, i.e ...