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In contrast, dominant monkeys experienced a decrease in cocaine self-administration and a rightward shift in the dose-response curve. Brain glucose metabolism measurements revealed differences between dominant and subordinate monkeys, shedding light on the underlying mechanisms of these opposing behavioral effects. Dominant monkeys showed ...
Cocaine is a non-selective, competitive inhibitor of monoamine transporters, sharing a similar mechanism with that of methylphenidate. Cocaine interacts with DAT, SERT, and NET, although the behavioral and reinforcing effects of cocaine depend on its inhibition of DAT and the increase in extracellular dopamine. [1]
This suggests a positive neuromodulatory action of CART on the effects of psychostimulants in rats. [18] CART is altered in the ventral tegmental area of cocaine overdose victims, and a mutation in the CART gene is associated with alcoholism. [19] By inhibiting the rewarding effects of cocaine, CART has a potential use in treating cocaine ...
The effects of cocaine are similar to those of amphetamines, though cocaine tends to have a shorter duration of effect. In high doses or with prolonged use, cocaine can result in a number of negative effects, including irritability, anxiety, exhaustion, total insomnia, and even psychotic symptomatology.
The effects of KOR agonism on dopamine systems are well documented, and recent work also implicates the mitogen-activated protein kinase cascade and pCREB in KOR-dependent behaviors. [ 40 ] [ 81 ] While the predominant drugs of abuse examined have been cocaine (44%), ethanol (35%), and opioids (24%). [ 82 ]
Different activities had varying effects on participants’ brain waves. Playing and walking with a dog increased the strength of the alpha-band oscillations, the authors found, which generally ...
Through lines of D1 receptor mutant mice, it had also been implicated in mediating both the locomotor sensation and rewarding effects of cocaine. Acute cocaine injections induced c-fos and CREB expression via D1 receptors and repeat cocaine administration, which is associated with long lasting AP-1 transcription complexes containing ΔFosB ...
A 2022 study found that veterans and first responders who had a service dog experienced fewer PTSD symptoms than those without one — though having a dog as a pet was less effective.