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Some of the symptoms that could possibly occur as a result of a withdrawal from benzodiazepines after long-term use include emotional clouding, [1] flu-like symptoms, [5] suicide, [11] nausea, headaches, dizziness, irritability, lethargy, sleep problems, memory impairment, personality changes, aggression, depression, social deterioration as ...
There are few side effects, other than vomiting, with short-term use. [1] [2] With long-term use anemia or numbness may occur. [2] It should always be given with at least 21% oxygen. [2] It is not recommended in people with a bowel obstruction or pneumothorax. [2] Use in the early part of pregnancy is not recommended. [1]
The higher the dose and the longer the drug is taken, the risk of experiencing unpleasant withdrawal symptoms becomes greater. Withdrawal symptoms can, however, occur at standard dosages and also after short-term use. Benzodiazepine treatment should be discontinued as soon as possible through a slow and gradual dose-reduction regime. [22]
The drug, suzetrigine, received the FDA's official stamp of approval Thursday to be sold as a 50-milligram prescription pill taken every 12 hours, according to a press release.
These side effects are serious and some of them are permanent, and many remain a crucial concern for companies and healthcare professionals and substantial efforts are being encouraged to reduce the potential risks for future antipsychotics through more clinical trials and drug development.
[20] [21] Long-term use can result in tolerance, dependence, and withdrawal symptoms on dose reduction. [15] Abrupt stopping after long-term use can be potentially dangerous. [15] After stopping, cognitive problems may persist for six months or longer. [20] It is not recommended during pregnancy or breastfeeding. [17]
More research is needed on Ozempic long-term side effects. Some severe side effects with long-term consequences may include pancreatitis, acute kidney injury, gallstones, gallbladder disease ...
To minimise the risk of physical/psychological dependence, lorazepam is best used only short-term, at the smallest effective dose. If any benzodiazepine has been used long-term, the recommendation is a gradual dose taper over weeks, months, or longer, according to dose and duration of use, the degree of dependence and the individual.