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That is: it is valid if it is an e-value. In fact, this reveals that e-values bounded to [, /] are rescaled randomized tests, that are continuously interpreted as evidence against the hypothesis. The standard e-value that takes value in [,] appears as a generalization of a level 0 test. [2]
The elimination rate constant K or K e is a value used in pharmacokinetics to describe the rate at which a drug is removed from the human system. [1] It is often abbreviated K or K e. It is equivalent to the fraction of a substance that is removed per unit time measured at any particular instant and has units of T −1.
Usually, clearance is measured in L/h or mL/min. [2] Excretion, on the other hand, is a measurement of the amount of a substance removed from the body per unit time (e.g., mg/min, μg/min, etc.). While clearance and excretion of a substance are related, they are not the same thing.
In the United States, the regulation of the pharmacist-to-pharmacy technician ratio is regulated at the individual state level. [1] Some states vary the ratio by institutional (e.g. hospital) pharmacy practice versus retail (i.e. community) pharmacy practice, while others do not regulate pharmacist-to-pharmacy technician ratios at all. [1]
The use of trapezoidal rule in AUC calculation was known in literature by no later than 1975, in J.G. Wagner's Fundamentals of Clinical Pharmacokinetics. A 1977 article compares the "classical" trapezoidal method to a number of methods that take into account the typical shape of the concentration plot, caused by first-order kinetics. [8]
The [A] at which E is 50% of E max is termed the half maximal effective concentration and is abbreviated EC 50, or rarely [A] 50. The term "potency" refers to the EC 50 value. The lower the EC 50 , the less the concentration of a drug is required to produce 50% of maximum effect and the higher the potency.
The Pharmacy Examining Board of Canada administers the Pharmacy Technician Qualifying Examination. Pharmacy technicians are required to be registered with a provincial or a national regulatory body or council. In provinces and jurisdictions where pharmacy technician is a regulated occupation, liability insurance is required to practice. [7] [8]
NNT may vary substantially over time, [9] [10] and hence convey different information as a function of the specific time-point of its calculation. Snapinn and Jiang [ 11 ] showed examples where the information conveyed by the NNT may be incomplete or even contradictory compared to the traditional statistics of interest in survival analysis.