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Most individuals with G6PD deficiency are asymptomatic.When it induces hemolysis, the effect is usually short-lived. [5]Most people who develop symptoms are male, due to the X-linked pattern of inheritance, but female carriers can be affected due to unfavorable lyonization or skewed X-inactivation, where random inactivation of an X-chromosome in certain cells creates a population of G6PD ...
G6PD converts G6P into 6-phosphoglucono-δ-lactone and is the rate-limiting enzyme of the pentose phosphate pathway. Thus, regulation of G6PD has downstream consequences for the activity of the rest of the pentose phosphate pathway. Glucose-6-phosphate dehydrogenase is stimulated by its substrate G6P.
Glucose-6-phosphate dehydrogenase deficiency is a common genetic condition, with a global prevalence of approximately 4.9%, affecting over 400 million individuals worldwide. [ 5 ] [ 6 ] It is important to recognize that glucose-6-phosphate dehydrogenase deficiency can still be life-threatening if not promptly diagnosed and managed.
People suffering from 6PGD or G6PD deficiency (or both) are at risk of hemolytic anemia in states of oxidative stress. Oxidative stress can result from infection and from chemical exposure to medication and certain foods. Broad beans, e.g., fava beans, contain high levels of vicine, divicine, convicine and isouramil, all of which are oxidants.
Various genetic studies on Filipinos have been performed, to analyze the population genetics of the various ethnic groups in the Philippines.. The results of a DNA study conducted by the National Geographic's "The Genographic Project", based on genetic testings of Filipino people by the National Geographic in 2008–2009, found that the Philippines is made up of around 53% Southeast Asia and ...
Then PNP Chief Ronald dela Rosa presents Kerwin Espinosa, who voluntarily surrendered himself to authorities, to the media. On August 1, 2016, Philippine President Rodrigo Duterte, who was conducting a nationwide campaign against illegal drugs, asked Espinosa and his son Kerwin to surrender themselves within 24 hours "on the grounds of drug-trafficking and coddling."
The Bolo knife was the primary weapon used by the Katipunan during the Philippine Revolution. [18] It was also used by the Filipino guerrillas and bolomen during the Philippine–American War. [19] [20] the bolo serves as a symbol for the Katipunan and the Philippine Revolution, particularly the Cry of Pugad Lawin.
This list of conflicts in the Philippines is a timeline of events that includes pre-colonial wars, Spanish–Moro conflict, Philippine revolts against Spain, battles, skirmishes, and other related items that have occurred in the Philippines' geographical area.