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Most individuals with G6PD deficiency are asymptomatic.When it induces hemolysis, the effect is usually short-lived. [5]Most people who develop symptoms are male, due to the X-linked pattern of inheritance, but female carriers can be affected due to unfavorable lyonization or skewed X-inactivation, where random inactivation of an X-chromosome in certain cells creates a population of G6PD ...
G6PD converts G6P into 6-phosphoglucono-δ-lactone and is the rate-limiting enzyme of the pentose phosphate pathway. Thus, regulation of G6PD has downstream consequences for the activity of the rest of the pentose phosphate pathway. Glucose-6-phosphate dehydrogenase is stimulated by its substrate G6P.
Glucose-6-phosphate dehydrogenase deficiency is a common genetic condition, with a global prevalence of approximately 4.9%, affecting over 400 million individuals worldwide. [ 5 ] [ 6 ] It is important to recognize that glucose-6-phosphate dehydrogenase deficiency can still be life-threatening if not promptly diagnosed and managed.
The Expanded Program on Immunization (EPI) in the Philippines began in 1976 [1] through Presidential Decree No. 996 signed by President Ferdinand Marcos. [2] And, in 1986, made a response to the Universal Child Immunization goal. The four major strategies include: [3]
Various genetic studies on Filipinos have been performed, to analyze the population genetics of the various ethnic groups in the Philippines.. The results of a DNA study conducted by the National Geographic's "The Genographic Project", based on genetic testings of Filipino people by the National Geographic in 2008–2009, found that the Philippines is made up of around 53% Southeast Asia and ...
This is a timeline of Philippine history, comprising important legal and territorial changes and political events in the Philippines and its predecessor states. To read about the background to these events, see history of the Philippines .
The 24-year-old cemented his legendary status after he took the top spot in the men’s floor and vault events, making him the first male athlete in the Philippines' history to win a gold medal.
The history of the Philippines dates from the earliest hominin activity in the archipelago at least by 709,000 years ago. [1] Homo luzonensis, a species of archaic humans, was present on the island of Luzon [2] [3] at least by 134,000 years ago. [4] The earliest known anatomically modern human was from Tabon Caves in Palawan dating about 47,000 ...