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Nicolae Constantin Paulescu (Romanian pronunciation: [nikoˈla.e pa.uˈlesku]; 30 October 1869 (O.S.) – 17 July 1931) was a Romanian physiologist, professor of medicine, and politician, most famous for his work on diabetes, including patenting pancreine (a pancreatic extract containing insulin).
Robert Derek Channon (born 15 June 1944) is a British engineer known for inventing an insulin pump for diabetics, and miniaturized helicopters for the UK military. [1] A diabetic himself, Channon developed the three ounce insulin pump to replace his own regular insulin injections. [2]
Insulin pumps, cartridges, and infusion sets may be far more expensive than syringes used for insulin injection with several insulin pumps costing more than $6,000; necessary supplies can cost over $300. [3] Another disadvantage of insulin pump use is a higher risk of developing diabetic ketoacidosis if the pump malfunctions. [3]
Douglas Grundy/Three Lions via Getty ImagesDiabetes was a fatal disease before insulin was discovered on July 27, 1921. A century ago, people diagnosed with this metabolic disorder usually ...
John Macleod was a distinguished physiologist even before the discovery of insulin. He was elected a member of the Royal Society of Canada in 1919 and president of American Physiological Society in 1921. [19] In 1923, Macleod was awarded the Cameron Prize for Therapeutics of the University of Edinburgh.
Their work led other doctors and scientists to pursue further research on the relation of the pancreas to diabetes, and ultimately resulted in the discovery of insulin as a treatment for the disease. Joseph von Mering, Oskar Minkowski: Diabetes mellitus nach Pankreasextirpation. Centralblatt für klinische Medicin, Leipzig, 1889, 10 (23): 393 ...
Hagedorn discovered that the addition of protamine to insulin caused the insulin to form microscopic clumps. These clumps took longer to dissolve into the bloodstream. This complex of protamine and insulin is known as NPH (neutral protamine Hagedorn) insulin. It is one of the earliest example of engineering drug delivery.
James Bertram Collip (November 20, 1892 – June 19, 1965) was a Canadian biochemist who was part of the Toronto group which isolated insulin.He served as the chair of the department of biochemistry at McGill University from 1928 to 1941 and dean of medicine at the University of Western Ontario from 1947 to 1961, where he was a charter member of The Kappa Alpha Society.
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