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9365 16591 Ensembl ENSG00000133116 ENSMUSG00000058488 UniProt Q9UEF7 O35082 RefSeq (mRNA) NM_004795 NM_153683 NM_013823 RefSeq (protein) NP_004786 NP_038851 Location (UCSC) Chr 13: 33.02 – 33.07 Mb Chr 5: 150.88 – 150.92 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Klotho is an enzyme that in humans is encoded by the KL gene. The three subfamilies of klotho are α-klotho, β ...
The mechanisms that underpin Klotho's enhancement of cognitive ability are still unknown. [7] Alongside working on mouse models, in 2019, Dubal was the first to show that Klotho may protect people from Alzheimer's disease. She demonstrated this by monitoring for the well-known Alzheimer's disease risk factors Apolipoprotein E (APOE) e4. [15]
A 2009 review of longevity research noted: "Extrapolation from worms to mammals is risky at best, and it cannot be assumed that interventions will result in comparable life extension factors. Longevity gains from dietary restriction, or from mutations studied previously, yield smaller benefits to Drosophila than to nematodes, and smaller still ...
Subcutaneous administration of longevity factor α-klotho enhanced cognition in old rhesus macaques. [252] In a paywalled review, the authors of a heavily cited paper on the hallmarks of aging update the set of proposed hallmarks after a decade. [253] [254] A review with overlapping authors merge or link various hallmarks of cancer with those ...
[5] [6] The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family and specifically a member of the endocrine subfamily which includes FGF23 and FGF15/19. FGF21 is the primary endogenous agonist of the FGF21 receptor, which is composed of the co-receptors FGF receptor 1 and β-Klotho. [7]
Klotho may refer to Klotho (Greek mythology) or Clotho, one of the Moirai, or Fates, in Greek mythology; 97 Klotho, an asteroid; Klotho (biology), a membrane protein;
The Biomarkers of Aging Consortium is currently examining the application of these biomarkers to identify longevity interventions and ways to validate them. [19] Moreover, open-source resources, such as the R package methylCIPHER [ 20 ] and the Python package pyaging [ 21 ] are available to the public as hubs for several biomarkers of aging.
The hand of an older adult Life expectancy in various countries of the world in 2019. Biogerontology is the sub-field of gerontology concerned with the biological aging process, its evolutionary origins, and potential means to intervene in the process. [1]