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One of the alternate reactions involving CBS is the condensation of cysteine with homocysteine to form cystathionine and hydrogen sulfide (H 2 S). [13] H 2 S in the brain is produced from L-cysteine by CBS. This alternative metabolic pathway is also dependent on adoMet. [14] CBS enzyme activity is not found in all tissues and cells.
The synthesis of O-acetylserine is catalyzed by serine acetyltransferase and together with O-acetylserine (thiol)lyase it is associated as enzyme complex named cysteine synthase. The formation of cysteine is the direct coupling step between sulfur (sulfur metabolism) and nitrogen assimilation in plants.
Cystathionine is an intermediate in the synthesis of cysteine from homocysteine. It is produced by the transsulfuration pathway and is converted into cysteine by cystathionine gamma-lyase (CTH). Biosynthetically, cystathionine is generated from homocysteine and serine by cystathionine beta synthase (upper reaction in the diagram below).
A feature of the native chemical ligation technique is that the product polypeptide chain contains cysteine at the site of ligation. The cysteine at the ligation site can be desulfurized to alanine, thus extending the range of possible ligation sites to include alanine residues. Other beta-thiol containing amino acids can be used for native ...
Cystine is the oxidized derivative of the amino acid cysteine and has the formula (SCH 2 CH(NH 2)CO 2 H) 2.It is a white solid that is poorly soluble in water. As a residue in proteins, cystine serves two functions: a site of redox reactions and a mechanical linkage that allows proteins to retain their three-dimensional structure.
The reverse transsulfuration pathway depicting the conversion of homocysteine to cysteine in reactions 5 and 6. Reaction 5 is catalyzed by cystathionine beta-synthase while reaction 6 is catalyzed by cystathionine gamma-lyase. The required homocysteine is synthesized from methionine in reactions 1, 2, and 3.
It is a homologue of the amino acid cysteine, differing by an additional methylene bridge (-CH 2-). It is biosynthesized from methionine by the removal of its terminal C ε methyl group. In the body, homocysteine can be recycled into methionine or converted into cysteine with the aid of vitamin B 6, B 9, and B 12. [3]
Cystamine (2,2'-dithiobisethanamine) is an organic disulfide.It is formed when cystine is heated, the result of decarboxylation.Cystamine is an unstable liquid and is generally handled as the dihydrochloride salt, C 4 H 12 N 2 S 2 ·2HCl, which is stable to 203-214 °C at which point it decomposes.