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Serotonin, being a tryptamine (non-catecholamine) involved in higher brain functions, can cause dangerous hypertension and tachycardia from its effects on the sympathetic nervous system. [23] Symptoms caused by excessive adrenergic signalling can occur alongside those of serotonergic signalling.
Excess catecholamines have been described as a dormant volcano, ready to erupt at any time, wreaking catastrophic havoc on the body. [108] While an eruption can occur at any time, two of the most common triggers are anesthesia and direct tumor manipulation, making surgery one of the most dangerous times for a pheochromocytoma patient if not ...
Excess catecholamines, when released directly by nerves that stimulate cardiac muscle cells, have a toxic effect and can lead to decreased cardiac muscular function or "stunning". [ 11 ] [ 12 ] Further, this adrenaline surge triggers the arteries to tighten , thereby raising blood pressure and placing more stress on the heart, and may lead to ...
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Paroxysmal sympathetic hyperactivity (PSH) is a syndrome that causes episodes of increased activity of the sympathetic nervous system.Hyperactivity of the sympathetic nervous system can manifest as increased heart rate, increased respiration, increased blood pressure, diaphoresis, and hyperthermia. [1]
Pheochromocytoma (most common), a catecholamine-secreting tumor of the adrenal medulla. [1] [5] Pheochromocytomas may generate sudden bursts of paroxysmal symptoms due to excess catecholamine secretion. In a classical presentation of these tumors, some symptoms that commonly occur are palpitations, sweating, and headaches; these last a variable ...
Catecholamines are produced mainly by the chromaffin cells of the adrenal medulla and the postganglionic fibers of the sympathetic nervous system. Dopamine, which acts as a neurotransmitter in the central nervous system, is largely produced in neuronal cell bodies in two areas of the brainstem: the ventral tegmental area and the substantia nigra, the latter of which contains neuromelanin ...
These blackouts often occur during exercise or as a response to emotional stress—situations in which chemical messengers known as catecholamines, such as adrenaline, are released within the body. Blackouts may be misinterpreted as being caused by simple faints or epilepsy , often leading to delays in reaching the correct diagnosis. [ 7 ]