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Neurogenic bowel dysfunction (NBD) is reduced ability or inability to control defecation due to deterioration of or injury to the nervous system, resulting in fecal incontinence or constipation. [1] It is common in people with spinal cord injury (SCI), multiple sclerosis (MS) or spina bifida .
A large fraction of cases are diagnosed after routine surgery for bowel obstruction. [4] Others may be diagnosed incidentally, or after investigation for carcinoid syndrome. The tumor typically produces serotonin, Tachykinin peptides and other substances, which cause flushing, tachycardia, diarrhea and in some cases fibrosis of the heart valves.
Fecal impaction is a common result of neurogenic bowel dysfunction and causes immense discomfort and pain. Its treatment includes laxatives, enemas, and pulsed irrigation evacuation (PIE) as well as digital removal. It is not a condition that resolves without direct treatment.
Neuroendocrine tumors (NETs) are neoplasms that arise from cells of the endocrine and nervous systems.They most commonly occur in the intestine, where they are often called carcinoid tumors, but they are also found in the pancreas, lung, and the rest of the body.
The signs and symptoms of colorectal cancer depend on the location of the tumor in the bowel, and whether it has spread elsewhere in the body ().The classic warning signs include: worsening constipation, blood in the stool, decrease in stool caliber (thickness), loss of appetite, loss of weight, and nausea or vomiting in someone over 50 years old. [15]
Pancreatic cancer is the fifth most-common cause of cancer-related deaths in the United States, [8] and the seventh most-common in Europe. [9] In 2008, globally there were 280,000 new cases of pancreatic cancer reported and 265,000 deaths. [10] These cancers are classified as endocrine or nonendocrine tumors. The most common is ductal ...
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Magnesium deficiency causes neurogenic inflammation in a rat model. Researchers have theorized that since substance P which appears at day five of induced magnesium deficiency, is known to stimulate in turn the production of other inflammatory cytokines including IL-1, Interleukin 6 (IL-6), and TNF-alpha (TNFα), which begin a sharp rise at day 12, substance P is a key in the path from ...
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