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Aripiprazole, sold under the brand names Abilify and Aristada, among others, is an atypical antipsychotic. [8] It is primarily used in the treatment of schizophrenia , bipolar disorder , and irritability associated with autism spectrum disorder ; [ 8 ] other uses include as an add-on treatment in major depressive disorder and tic disorders . [ 8 ]
Antipsychotics are completely metabolized in the body and the metabolites are excreted in urine. [56] These drugs have relatively long half-lives. [56] Each drug has a different half-life, but the occupancy of the D2 receptor falls off within 24 hours with atypical antipsychotics, while lasting over 24 hours for the typical antipsychotics. [64]
Drug metabolism is the metabolic breakdown of drugs by living organisms, usually through specialized enzymatic systems. More generally, xenobiotic metabolism (from the Greek xenos "stranger" and biotic "related to living beings") is the set of metabolic pathways that modify the chemical structure of xenobiotics, which are compounds foreign to an organism's normal biochemistry, such as any drug ...
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An important limitation of all these studies is the single-gene analysis, since most drugs that are metabolized by CYP2C19 are also metabolized by CYP2D6 and CYP3A4 enzymes. Besides that, other genes are involved in drug response, for example, escitalopram is transported by P-glycoprotein , encoded by the ABCB1 gene.
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When it comes to losing weight, there are no shortage of unproven recommendations to choose from: fad diets like the carnivore diet or GOLO diet; juice cleanses and vitamin injections; plus a host ...
Meet the experts: Carla Prado, PhD, RD, is the Canada Research Chair in Integrative Nutrition, Body Composition, and Energy Metabolism at the University of Alberta.