Search results
Results from the WOW.Com Content Network
Dimethylamine is a weak base and the pKa of the ammonium CH 3-NH + 2-CH 3 is 10.73, a value above methylamine (10.64) and trimethylamine (9.79). Dimethylamine reacts with acids to form salts, such as dimethylamine hydrochloride, an odorless white solid with a melting point of 171.5 °C.
The same vinamidinium salt 1,1,5,5-tetramethyl-1,5-diazapentadienium chloride is also formed in the reaction of 3-dimethylaminoacrolein with dimethylamine hydrochloride in 70% yield. [21] The two-step reaction of dimethylamine and 70% perchloric acid with 3-dimethylaminoacrolein forms the same iminium salt (herein referred to as 1,3-bis ...
A closely related method involves combining dimethylcarbamoyl chloride with excess dimethylamine Even though the product is contaminated and smelly it may be purified by addition of calcium oxide and subsequent fractional distillation. [3] This reactions is highly exothermic. The removal of the resulting dimethylamine hydrochloride requires ...
Hydrochloride salt: 112 to 115 °C (234 to 239 °F; 385 to 388 ... 43.2 [2] Except where otherwise noted, data are given for materials in their standard state (at 25 ...
1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC, EDAC or EDCI) is a water-soluble carbodiimide usually handled as the hydrochloride. [1] It is typically employed in the 4.0-6.0 pH range. It is generally used as a carboxyl activating agent for the coupling of primary amines to yield amide bonds.
DMA is prepared commercially by the reaction of dimethylamine with acetic anhydride or acetic acid. Dehydration of the salt of dimethylamine and acetic acid also furnishes this compound: [5] CH 3 CO 2 H·HN(CH 3) 2 → H 2 O + CH 3 CON(CH 3) 2. Dimethylacetamide can also be produced by the reaction of dimethylamine with methyl acetate. [6]
Pfizer said it plans to present the data at an upcoming medical meeting and discuss it with global health regulators for a potential approval. The drug is an anti-PD-1 monoclonal antibody, the ...
NDMA forms from a variety of dimethylamine-containing compounds, e.g. hydrolysis of dimethylformamide. Dimethylamine is susceptible to oxidation to unsymmetrical dimethylhydrazine, which air-oxidizes to NDMA. [15] In the laboratory, NDMA can be synthesised by the reaction of nitrous acid with dimethylamine: HONO + (CH 3) 2 NH → (CH 3) 2 NNO ...