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Ferritin genes are highly conserved between species. All vertebrate ferritin genes have three introns and four exons. [8] In human ferritin, introns are present between amino acid residues 14 and 15, 34 and 35, and 82 and 83; in addition, there are one to two hundred untranslated bases at either end of the combined exons. [9]
Serum iron is a medical laboratory test that measures the amount of circulating iron that is bound to transferrin and freely circulate in the blood. Clinicians order this laboratory test when they are concerned about iron deficiency, which can cause anemia and other problems. 65% of the iron in the body is bound up in hemoglobin molecules in red blood cells.
Iron tests are groups of clinical chemistry laboratory blood tests that are used to evaluate body iron stores or the iron level in blood serum.. Other terms used for the same tests are iron panel, iron profile, iron indices, iron status or iron studies.
serum ferritin [4] bone marrow examination (rarely) [4] Note: Iron therapy must be suspended 48 hours beforehand to ensure valid test results. [4] The normal range for hemoglobin is 13.8 to 17.2 grams per deciliter (g/dL) for men and 12.1 to 15.1 g/dL for women. [6] Low hemoglobin indicates anemia but will be normal for LID. [5]
Proinflammatory states account for up to 90% of raised ferritin. [57] [58] [4] Serum ferritin in excess of 1000 ng/mL of blood is almost always attributable to haemochromatosis. [citation needed] Other blood tests routinely performed include blood count, renal function, liver enzymes, electrolytes, and glucose (and/or an oral glucose tolerance ...
Taken together with serum iron and percent transferrin saturation clinicians usually perform this test when they are concerned about anemia, iron deficiency or iron deficiency anemia. However, because the liver produces transferrin, alterations in function (such as cirrhosis, hepatitis, or liver failure) must be considered when performing this ...
Serum ferritin is a low cost, readily available, and minimally invasive method for assessing body iron stores. However, the major problem with using it as an indicator of hemosiderosis is that it can be elevated in a range of other medical conditions unrelated to iron levels including infection, inflammation, fever, liver disease, renal disease ...
Section of liver stained with Perls Prussian blue, showing iron accumulations (blue) consistent with homozygous genetic hemochromatosis. Perls's method is used to indicate "non-heme" iron in tissues such as ferritin and hemosiderin, [6] the procedure does not stain iron that is bound to porphyrin forming heme such as hemoglobin and myoglobin. [2]