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Unregulated PAF signaling can cause pathological inflammation and has been found to be a cause in sepsis, shock, and traumatic injury. PAF can be used as a local signaling molecule and travel over very short distances or it can be circulated throughout the body and act via endocrine. PAF initiates an inflammatory response in allergic reactions. [7]
The platelet-activating factor receptor (PAF-R) is a G-protein coupled receptor which binds platelet-activating factor. [ 5 ] [ 6 ] It is encoded in the human by the PTAFR gene . The PAF receptor shows structural characteristics of the rhodopsin (MIM 180380) gene family and binds platelet-activating factor (PAF).
Pure autonomic failure (PAF) is an uncommon, sporadic neurodegenerative condition marked by a steadily declining autonomic regulation. [3] Bradbury and Eggleston originally described pure autonomic failure in 1925. [4] Patients usually present with orthostatic hypotension or syncope in midlife or later.
PAF+acetylhydrolase at the U.S. National Library of Medicine Medical Subject Headings (MeSH) EC 3.1.1.47 This page was last edited on 22 September 2024, at 16:21 ...
Lipoprotein-associated phospholipase A 2 (Lp-PLA 2) also known as platelet-activating factor acetylhydrolase (PAF-AH) is a phospholipase A 2 enzyme that in humans is encoded by the PLA2G7 gene. [5] [6] Lp-PLA 2 is a 45-kDa protein of 441 amino acids. [7] It is one of several PAF acetylhydrolases.
Primary autonomic failure (also called primary dysautonomia) refers to a category of dysautonomias — conditions in which the autonomic nervous system does not function properly.
Emotional dysregulation is characterized by an inability to flexibly respond to and manage emotional states, resulting in intense and prolonged emotional reactions that deviate from social norms, given the nature of the environmental stimuli encountered.
Protactinium tetrafluoride is a binary inorganic compound of protactinium metal and fluorine with the chemical formula PaF 4. [1] Synthesis