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Trifluoroacetic acid in a beaker. TFA is the precursor to many other fluorinated compounds such as trifluoroacetic anhydride, trifluoroperacetic acid, and 2,2,2-trifluoroethanol. [4] It is a reagent used in organic synthesis because of a combination of convenient properties: volatility, solubility in organic solvents, and its strength as an ...
Most manufacturers publish compatibility wallcharts advising users of compatibility between their products and organic solvents or corrosive liquids (e.g. trifluoroacetic acid). Application [ edit ]
Trifluoroacetic acid is a widely employed acid, used for example in the synthesis of peptides.Its esters are useful in analytical chemistry. Longer-chain perfluoroalkyl carboxylic acids, e.g. with five to nine carbons, are useful fluorosurfactants and emulsifiers used in the production of polytetrafluoroethylene (Teflon) and related fluoropolymers.
Trifluoroacetic anhydride was originally prepared by the dehydration of trifluoroacetic acid with phosphorus pentoxide. [2] The dehydration might also be carried out with excess α-halogenated acid chlorides. For example, with dichloroacetyl chloride: [3] 2 CF 3 COOH + Cl 2 CHCOCl → (CF 3 CO) 2 O + Cl 2 CHCOOH + HCl
Chemical compatibility is a rough measure of how stable a substance is when mixed with another substance. [1] If two substances can mix together and not undergo a chemical reaction, they are considered compatible. Incompatible chemicals react with each other, and can cause corrosion, mechanical weakening, evolution of gas, fire, or other ...
This page contains tables of azeotrope data for various binary and ternary mixtures of solvents. The data include the composition of a mixture by weight (in binary azeotropes, when only one fraction is given, it is the fraction of the second component), the boiling point (b.p.) of a component, the boiling point of a mixture, and the specific gravity of the mixture.
Trifluoroethanol is produced industrially by hydrogenation or the hydride reduction of derivatives of trifluoroacetic acid, such as the esters or acyl chloride. [1]TFE can also be prepared by hydrogenolysis of compounds of generic formula CF 3 −CHOH−OR (where R is hydrogen or an alkyl group containing from one to eight carbon atoms), in the presence of a palladium containing catalyst ...
The trifluoromethyl group has a significant electronegativity that is often described as being intermediate between the electronegativities of fluorine and chlorine. [1] For this reason, trifluoromethyl-substituted compounds are often strong acids, such as trifluoromethanesulfonic acid and trifluoroacetic acid.