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Capillary electrophoresis (CE) is a family of electrokinetic separation methods performed in submillimeter diameter capillaries and in micro- and nanofluidic channels.Very often, CE refers to capillary zone electrophoresis (CZE), but other electrophoretic techniques including capillary gel electrophoresis (CGE), capillary isoelectric focusing (CIEF), capillary isotachophoresis and micellar ...
Changes in temperature affect the viscosity and surface tension of the blood, altering the minimum blood flow rate. At high temperatures the minimum flow rate will decrease and the capillary will expand. This allows heat transfer through the increased surface area of the inner capillary lining and through increased blood flow.
The rate at which fluid is filtered across vascular endothelium (transendothelial filtration) is determined by the sum of two outward forces, capillary pressure and colloid osmotic pressure beneath the endothelial glycocalyx (), and two absorptive forces, plasma protein osmotic pressure and interstitial pressure (). The Starling equation is the ...
Differences in vascular permeability between normal tissue and a tumor. Vascular permeability, often in the form of capillary permeability or microvascular permeability, characterizes the capacity of a blood vessel wall to allow for the flow of small molecules (drugs, nutrients, water, ions) or even whole cells (lymphocytes on their way to the site of inflammation) in and out of the vessel.
Some capillary techniques provide also a chamber like arrangement, however, there is no filter between the cells and the test substance. [5] Quantitative results are gained by the multiwell type of this probe using 4-8-12-channel pipettes. Accuracy of the pipette and increased number of the parallel running samples is the great advantage of ...
Exchange surface. Presence of natural barriers. These are obstacles to a drug's diffusion similar to those encountered during its absorption. The most interesting are: Capillary bed permeability, which varies between tissues. Blood-brain barrier: this is located between the blood plasma in the cerebral blood vessels and the brain's ...
Two well resolved peaks in a chromatogram. The plate height given as: = with the column length and the number of theoretical plates can be estimated from a chromatogram by analysis of the retention time for each component and its standard deviation as a measure for peak width, provided that the elution curve represents a Gaussian curve.
Capillary electrophoresis–mass spectrometry (CE–MS) is an analytical chemistry technique formed by the combination of the liquid separation process of capillary electrophoresis with mass spectrometry. [1] CE–MS combines advantages of both CE and MS to provide high separation efficiency and molecular mass information in a single analysis. [2]