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Photophobia is a medical symptom of abnormal intolerance to visual perception of light. [1] As a medical symptom, photophobia is not a morbid fear or phobia, but an experience of discomfort or pain to the eyes due to light exposure or by presence of actual physical sensitivity of the eyes, [2] though the term is sometimes additionally applied to abnormal or irrational fear of light, such as ...
Some drugs have a photosensitizing effect. Properties of natural or artificial light that may abnormally affect people include: Timing of light (upset of normal circadian rhythms, seasonal affective disorder, sleep disorders) Intensity of light (photophobia, sunburn, skin cancer) [1] [2] [3] Wavelength of light (in lupus, urticaria)
Particular medications make the skin more sensitive to sunlight; these include most of the tetracycline antibiotics, heart drugs amiodarone, and sulfonamides. Some dietary supplements, such as St. John's Wort, include photosensitivity as a possible side effect. Particular conditions lead to increased light sensitivity.
Antimetabolite medications, such as methotrexate are often used for recalcitrant or more aggressive cases of uveitis. Experimental treatments with Infliximab or other anti-TNF infusions may prove helpful. The anti-diabetic drug metformin is reported to inhibit the process that causes the inflammation in uveitis. [33]
some prescribed medications (such as tetracycline antibiotics); and; many essential oils, perfumes and cosmetics. Ingested medications may cause systemic photosensitivity and topically applied medications, cosmetics and essential oils may lead to local (or perhaps systemic) photosensitivity.
Many synthetic compounds, including drug substances like tetracyclines or fluoroquinolones, are known to cause these effects. Surface contact with some such chemicals causes photodermatitis, and many plants cause phytophotodermatitis. Light-induced toxicity is a common phenomenon in humans; however, it also occurs in other animals.
The primary causes include post-cataract surgery, certain medications, and, less commonly, neurological or ophthalmological conditions. Post-cataract surgery is a common cause, as replacing the natural lens with a synthetic one increases exposure to blue light, leading to temporary blue-tinted vision. This effect usually resolves as the eye adapts.
Herpes meningitis is typically self-limiting over 2 weeks without treatment. However, empirical use of antiviral medications such as acyclovir are considered in cases of suspected HSV meningitis to prevent progression to the more rapid and fatal HSV meningoencephalitis. [7] HSV-2 is the most common herpes virus that causes meningitis. [3]