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2. Meloxicam/rizatriptan - Wikipedia

   en.wikipedia.org/wiki/Meloxicam/rizatriptan

   Meloxicam/rizatriptan, sold under the brand name Symbravo, is a fixed-dose combination medication used for the treatment of migraine. [1] It is a combination of meloxicam , a nonsteroidal anti-inflammatory medication ; and rizatriptan (as rizatriptan benzoate), a serotonin (5-HT) 1B/1D receptor agonist ( triptan ). [ 1 ]

3. Rizatriptan - Wikipedia

   en.wikipedia.org/wiki/Rizatriptan

   Rizatriptan was patented in 1991 and came into medical use in 1998. [5] [6] It is available as a generic medication. [4] In 2022, it was the 190th most commonly prescribed medication in the United States, with more than 2 million prescriptions. [7] [8] Rizatriptan is available in combination with meloxicam as meloxicam/rizatriptan.

4. New migraine drugs ‘comparable to paracetamol’, researchers ...

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5. Naratriptan - Wikipedia

   en.wikipedia.org/wiki/Naratriptan

   A meta-analysis of 53 clinical trials has shown that all triptans are effective for treating migraine at marketed doses and that naratriptan, although less effective than sumatriptan and rizatriptan was more effective than placebo in reducing migraine symptoms at two hours [3] and efficacy was demonstrated in almost two thirds of subjects after four hours of treatment.

6. Triptan - Wikipedia

   en.wikipedia.org/wiki/Triptan

   The most common adverse effect is recurrence of migraine. A systematic review found that "rizatriptan 10 mg was the only triptan with a recurrence rate greater than that of placebo". [24] There is a theoretical risk of coronary spasm in patients with established heart disease, and cardiac events after taking triptans may rarely occur. [25]

7. Antimigraine drug - Wikipedia

   en.wikipedia.org/wiki/Antimigraine_drug

   They show activity at serotonin 5-HT 1-2, dopamine D2-like and alpha1/alpha2-adrenoreceptors. [4] Their lack of selectivity leads to more adverse effects, making them second line compared to triptans. [4] However, they have been shown to prevent recurrence better than triptans. [5] Adverse effects include nausea, vomiting, paresthesia, and ...

8. Discovery and development of triptans - Wikipedia

   en.wikipedia.org/wiki/Discovery_and_development...

   Sumatriptan [4] binds to 5-HT 1D receptors, zolmitriptan, [5] rizatriptan, [6] naratriptan, [7] almotriptan, [8] and frovatriptan [9] binds to 5-HT 1B/1D and eletriptan [10] binds to 5-HT 1B/1D/1F receptors. Triptans are believed to exert their effects through vasoconstriction, leading to reduced carotid arterial circulation without affecting ...

9. Almotriptan - Wikipedia

   en.wikipedia.org/wiki/Almotriptan

   Like all triptans, almotriptan has a high and specific affinity for serotonin 5-HT 1B/1D receptors. Binding of the drug to the receptor leads to vasoconstriction of the cranial (brain) blood vessels and thus affects the redistribution of blood flow. Almotriptan significantly increases cerebral blood flow and reduces blood flow through ...