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Lamotrigine is metabolized predominantly by glucuronic acid conjugation. Its major metabolite is an inactive 2-n-glucuronide conjugate. [82] Lamotrigine has fewer drug interactions than many anticonvulsant drugs, although pharmacokinetic interactions with carbamazepine, phenytoin and other hepatic enzyme-inducing medications may shorten half ...
[1] As of 2021, about 51 million people have epilepsy. Nearly 80% of cases occur in the developing world. [1] [8] In 2021, it resulted in 140,000 deaths, an increase from 125,000 in 1990. [9] [14] [15] Epilepsy is more common in children and older people.
The σ 1 receptor is defined by its unique pharmacological profile. In 1976 Martin reported that the effects of N-allylnormetazocine (SKF-10,047) could not be due to activity at the μ and κ receptors (named from the first letter of their selective ligands morphine and ketazocine, respectively) and a new type of opioid receptor was proposed; σ (from the first letter of SKF-10,047). [13]
An alcoholic beverage is a drink that contains alcohol (known formally as ethanol), an anesthetic that has been used as a psychoactive drug for several millennia.Ethanol is the oldest recreational drug still used by humans.
Jetstar Boeing 787 fact sheet. A factsheet or fact sheet, also called fact file, is a single-page document containing essential information about a product, substance, service or other topic. Factsheets are frequently used to provide information to an end user, consumer or member of the public in concise, simple language. They generally contain ...
RR 1.31 (1.16 to 1.47) Moderate: Leaving the study early for any reason: Valproate in combination with antipsychotics may slightly reduce the chance of leaving the study early, but the difference between the two treatments is not clear. Data supporting this finding are based on moderate quality evidence. RR 0.76 (0.47 to 1.24) Moderate
A study, as part of a series [429] and alongside a WHO fact sheet [image needed] (21 Mar), [430] [431] robustifies the recent [432] concept of "commercial determinants of health" suggesting "transnational corporations", facilitated by economic and governance systems [433] and a "shift towards market fundamentalism", are responsible for ...
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