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Primary hyperparathyroidism (or PHPT) is a medical condition where the parathyroid gland (or a benign tumor within it) produce excess amounts of parathyroid hormone (PTH). ). The symptoms of the condition relate to the resulting elevated serum calcium (hypercalcemia), which can cause digestive symptoms, kidney stones, psychiatric abnormalities, and bone dis
Primary hyperparathyroidism is the most common type. [1] Certain exposures increase the risk of developing primary hyperparathyroidism such as sex and age. It occurs three times more often in women than men and is often diagnosed between the ages of 50 and 60 but is not uncommon before then. [2] The disease was first described in the 1700s. [32]
Hyperparathyroidism is most commonly caused by a benign proliferation of chief cells in one parathyroid gland, and rarely in MEN syndrome. This is known as primary hyperparathyroidism, [13] which is generally managed by surgical removal of the abnormal parathyroid gland. [14]
Household pets such as dogs and cats are found to develop hypercalcemia. It is less common in cats, and many feline cases are idiopathic. [29] In dogs, lymphosarcoma, Addison's disease, primary hyperparathyroidism, and chronic kidney failure are the main causes of hypercalcemia, but there are also environmental causes usually unique to indoor ...
Hyperparathyroidism was first described in 1925 and the symptoms have collectively become known as "moans, groans, stones, and bones." By far, the most common symptom is fatigue, but depression, memory loss, and bone aches are also very common. Primary hyperparathyroidism is relatively more common in postmenopausal women.
Nephrocalcinosis, once known as Albright's calcinosis after Fuller Albright, is a term originally used to describe the deposition of poorly soluble calcium salts in the renal parenchyma due to hyperparathyroidism. The term nephrocalcinosis is used to describe the deposition of both calcium oxalate and calcium phosphate. [1]
A parathyroid adenoma is the most common cause of hyperparathyroidism. [2] They are more commonly found in women than in men. In this form, the chief cells mutate to exhibit multiple nuclei. [2] Chief cells in parathyroid adenomas also display acid phosphatase activity. [5] It is a benign tumor of the gland that requires surgical removal. [13]
Hyperparathyroidism. Primary hyperparathyroidism; Secondary hyperparathyroidism; Tertiary hyperparathyroidism; Hyperparathyroid myopathy [6] Hypoparathyroidism. Pseudohypoparathyroidism; Hypoparathyroid myopathy [6] Osteoporosis; Osteitis deformans (Paget's disease of bone) Rickets; Osteomalacia
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