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The argument proposes that there are different motives behind defining causality; the Bradford Hill criteria applied to complex systems such as health sciences are useful in prediction models where a consequence is sought; explanation models as to why causation occurred are deduced less easily from Bradford Hill criteria because the instigation ...
In the field of epidemiology, the causal mechanisms responsible for diseases can be understood using the causal pie model.This conceptual model was introduced by Ken Rothman to communicate how constellations of component causes can lead to a sufficient cause to lead to a condition of interest and that reflection on these sets could improve epidemiological study design.
The subclinical (pre-symptomatic) and clinical (symptomatic) evolution of disease is the natural progression of a disease without any medical intervention. It constitutes the course of biological events that occurs during the development of the origin of the diseases [4] to its outcome, whether that be recovery, chronicity, or death. [5]
More modern concepts in microbial pathogenesis cannot be examined using Koch's postulates, including viruses (which are obligate intracellular parasites) and asymptomatic carriers. They have largely been supplanted by other criteria such as the Bradford Hill criteria for infectious disease causality in modern public health and the Molecular ...
The following outline is provided as an overview of and topical guide to concepts related to infectious diseases in humans.. Infection – transmission, entry/invasion after evading/overcoming defense, establishment, and replication of disease-causing microscopic organisms (pathogens) inside a host organism, and the reaction of host tissues to them and to the toxins they produce.
Ecosocial theory, first proposed by name in 1994 by Nancy Krieger of the Harvard T.H. Chan School of Public Health, [1] is a broad and complex theory with the purpose of describing and explaining causal relationships in disease distribution.
An etiological agent of disease may require an independent co-factor, and be subject to a promoter (increases expression) to cause disease. An example of all the above, which was recognized late, is that peptic ulcer disease may be induced by stress, requires the presence of acid secretion in the stomach, and has primary etiology in ...
Epidemiology has its limits at the point where an inference is made that the relationship between an agent and a disease is causal (general causation) and where the magnitude of excess risk attributed to the agent has been determined; that is, epidemiology addresses whether an agent can cause disease, not whether an agent did cause a specific ...