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Large granular lymphocytic (LGL) leukemia is a chronic lymphoproliferative disorder that exhibits an unexplained, chronic (> 6 months) elevation in large granular lymphocytes (LGLs) in the peripheral blood. [1] It is divided in two main categories: T-cell LGL leukemia (T-LGLL) and natural-killer (NK)-cell LGL leukemia (NK-LGLL).
T-cell leukemia describes several different types of lymphoid leukemia which affect T cells. Types include: [1] Large granular lymphocytic leukemia; Adult T-cell leukemia/lymphoma; T-cell prolymphocytic leukemia; In practice, it can be hard to distinguish T-cell leukemia from T-cell lymphoma, and they are often grouped together.
Natural killer cells, also known as NK cells, are a type of cytotoxic lymphocyte critical to the innate immune system.They are a kind of large granular lymphocytes [1] [2] (LGL), and belong to the rapidly expanding family of known innate lymphoid cells (ILC) and represent 5–20% of all circulating lymphocytes in humans. [3]
[13] In children who are cancer-free five years after diagnosis of acute leukemia, the cancer is unlikely to return. [13] In 2015, leukemia was present in 2.3 million people worldwide and caused 353,500 deaths. [7] [8] In 2012, it had newly developed in 352,000 people. [10]
Aggressive NK-cell leukemia is a disease with an aggressive, systemic proliferation of natural killer cells (NK cells) and a rapidly declining clinical course. [ 1 ] [ 2 ] [ 3 ] It is also called aggressive NK-cell lymphoma .
Thomas P. Loughran, Jr. is an American physician-scientist who specializes in cancer research and treatment. He became director of the University of Virginia Cancer Center, F. Palmer Weber-Smithfield Foods Professor of Oncology Research and Professor of Medicine at the University of Virginia on August 15, 2013. [1]
The most common T-cell leukemia is precursor T-cell lymphoblastic leukemia. [1] It causes 15% of acute leukemias in childhood, and also 40% of lymphomas in childhood. [1] It is most common in adolescent males. [1] Its morphology is identical to that of precursor B-cell lymphoblastic leukemia. [1] Cell markers include TdT, CD2, CD7. [1]
Chronic leukemia is an increase of abnormal white blood cells. It differs from acute leukemia, and is categorized as myelogenous, lymphocytic or myeloproliferative. Chronic leukemia may refer to: Chronic myelogenous leukemia; Chronic lymphocytic leukemia, including Hairy cell leukemia