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Rodenticides are chemicals made and sold for the purpose of killing rodents. While commonly referred to as "rat poison", rodenticides are also used to kill mice, woodchucks, chipmunks, porcupines, nutria, beavers, [1] and voles. [2] Some rodenticides are lethal after one exposure while others require more than one.
Norbormide (Raticate, Shoxin) is a toxic compound used as a rodenticide.It has several mechanisms of action, acting as a vasoconstrictor and calcium channel blocker, [1] but is selectively toxic to rats and has relatively low toxicity to other species, due to a species specific action of opening the permeability transition pores in rat mitochondria.
Similar to other rodenticides, the preparation requires 3–7 days to be effective. Rather than killing rodents through internal haemorrhaging as anticoagulants do, [9] PCC affects a rodent’s digestive system, causing acute dehydration due to its extremely absorptive nature (corn cob has been used in applications such as oil spills in water bodies, seed drying and de-icing). [10]
Brodifacoum is a highly lethal 4-hydroxycoumarin vitamin K antagonist anticoagulant poison.In recent years, it has become one of the world's most widely used pesticides.It is typically used as a rodenticide, but is also used to control larger pests such as possums.
Lethal dose or concentration (LD, LC): LD 50 (median dose) 280 mg/kg (rat, oral) ... It is commonly used as a rodenticide in the management of rat and rabbit populations.
In most countries, pesticides must be approved for sale and use by a government agency. [5] In the US, EPA is responsible for regulating pesticides under the Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) and the Food Quality Protection Act (FQPA). [6]
Chlorophacinone is a first-generation anticoagulant rodenticide. The mechanism of action results in internal bleeding due to non-functional clotting factors. It was used as a toxin to control rodent populations.
1080 is used as a rodenticide in Mexico, Japan, Korea, and Israel. [ 4 ] [ 51 ] In Israel 0.05% sodium fluoroacetate whole wheat grain baits are used to prevent heavy crop loss to field crops during mass outbreaks of the field rodents Microtus guentheri , Meriones tristrami and Mus musculus populations.
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