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Children (1–18 years): 15 mcg or 600 IU. Adults (18–70 years): 15 mcg or 600 IU. Older adults (over 70 years): 20 mcg or 800 IU. Sources of vitamin D. Vitamin D can be obtained from several ...
The EFSA reviewed safe levels of intake in 2012, [167] setting the tolerable upper limit for adults at 100 μg/day (4000 IU), a similar conclusion as the IOM. The Swedish National Food Agency recommends a daily intake of 10 μg (400 IU) of vitamin D 3 for children and adults up to 75 years, and 20 μg (800 IU) for adults 75 and older. [175]
The Institute of Medicine in 2010 recommended a maximum uptake of vitamin D of 4000 IU/d, finding that the dose for lowest observed adverse effect level is 40,000 IU daily for at least 12 weeks, [25] and that there was a single case of toxicity above 10 000 IU after more than seven years of daily intake; this case of toxicity occurred in ...
Ish-Shalom et al. [69] performed a study in elderly women to compare the efficacy and safety of a daily dose of 1500 IU to a weekly dose of 10 500 IU and to a dose of 45 000 IU given every 28 days for two months. They concluded that supplementation with vitamin D can be equally achieved with daily, weekly, or monthly dosing frequencies.
Endogenous production with full body exposure to sunlight is comparable to taking an oral dose between 250 μg and 625 μg (10,000 IU and 25,000 IU) per day. [7] [8] Vitamin D oral supplementation and skin synthesis have a different effect on the transport form of vitamin D, plasma calcifediol concentrations.
At a typical intake of cholecalciferol (up to 2000 IU/day), conversion to calcifediol is rapid. When large doses are given (100,000 IU), it takes 7 days to reach peak calcifediol concentrations. [9] Calcifediol binds in the blood to vitamin D-binding protein (also known as gc-globulin) and is the main circulating vitamin D metabolite.
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1540 Olentangy River Rd, Columbus, OH · Directions · (614) 299-2253
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