Search results
Results from the WOW.Com Content Network
GAD 67 is a key enzyme involved in the synthesis of inhibitory neurotransmitter GABA and people with schizophrenia have been shown to express lower amounts of GAD 67 in the dorsolateral prefrontal cortex compared to healthy controls. [40] The mechanism underlying the decreased levels of GAD 67 in people with schizophrenia remains unclear. [41]
Glutamate decarboxylase 1 (brain, 67kDa) (GAD67), also known as GAD1, is a human gene. [5] This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid.
Glutamic acid ball and stick model spinning. Glutamic acid (symbol Glu or E; [4] known as glutamate in its anionic form) is an α-amino acid that is used by almost all living beings in the biosynthesis of proteins.
In the brain of a mature mammal, glutamate is converted to GABA by the enzyme glutamate decarboxylase (GAD) along with the addition of vitamin B6. GABA is then packed and released into the post-synaptic terminals of neurons after synthesis. GABA can also be used to form succinate, which is involved in the citric acid cycle.
In biochemistry, the glutamate–glutamine cycle is a cyclic metabolic pathway which maintains an adequate supply of the neurotransmitter glutamate in the central nervous system. [1] Neurons are unable to synthesize either the excitatory neurotransmitter glutamate , or the inhibitory GABA from glucose .
The Food and Drug Administration (FDA) recently approved the nasal spray Spravato for the treatment of major depression in people who have not responded to at least two oral antidepressants.
Understaffed and overworked air traffic control crews have long been an issue at Reagan National and other airports, lawmakers say, and could have contributed to the nation’s deadliest air crash ...
Josh Gad is opening up about the weight loss success he’s had with GLP-1 medication — and sharing some of the conflicted feelings he’s had along the way. “I'm on a GLP-1 … this is the ...