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A Clarinase Repetab tablet contains 5 mg loratadine in the tablet coating and 120 mg pseudoephedrine sulfate equally distributed between the tablet coating and the barrier-coated core. The two active components in the coating are quickly liberated; release of pseudoephedrine in the core is delayed for several hours.
Loratadine, sold under the brand name Claritin among others, is a medication used to treat allergies. [5] This includes allergic rhinitis (hay fever) and hives. [5] It is also available in drug combinations such as loratadine/pseudoephedrine, in which it is combined with pseudoephedrine, a nasal decongestant. [5] It is taken orally. [5]
Pseudoephedrine is excreted through urine, and the concentration in urine of this drug shows a large inter-individual spread; that is, the same dose can give a vast difference in urine concentration for different individuals. [123]
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The dose of cyproheptadine recommended to ensure blockade of the 5-HT 2 receptors for serotonin syndrome is 20 to 30 mg. [30] Besides its activity at neurotransmitter targets, cyproheptadine has been reported to possess weak antiandrogenic activity. [33]
Consultation of a medical professional is recommended for those who intend to take antihistamines for longer-term use. [ 1 ] Although the general public typically uses the word "antihistamine" to describe drugs for treating allergies, physicians and scientists use the term to describe a class of drug that opposes the activity of histamine ...
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