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  2. MOG antibody disease - Wikipedia

    en.wikipedia.org/wiki/MOG_antibody_disease

    Serum anti-myelin oligodendrocyte glycoprotein antibodies are present in up to half of patients with an acquired demyelinating syndrome and have been described in association with a range of phenotypic presentations, including acute disseminated encephalomyelitis, optic neuritis, transverse myelitis, and neuromyelitis optica. [2]

  3. Myelin oligodendrocyte glycoprotein - Wikipedia

    en.wikipedia.org/wiki/Myelin_oligodendrocyte...

    Alternatively spliced human mRNA of the MOG gene form at least nine isoforms. [12] The crystal structure of myelin oligodendrocyte glycoprotein was determined by x-ray diffraction at a resolution of 1.45 Angstroms, using protein from the Norway rat. This protein is 139 residues long, and is a member of the immunoglobulin superfamily. [13]

  4. Neuromyelitis optica spectrum disorder - Wikipedia

    en.wikipedia.org/wiki/Neuromyelitis_optica...

    The second most frequent autoantibody in NMO is MOG-IgG, which targets myelin oligodendrocyte glycoprotein (MOG). MOG is an integral membrane glycoprotein found on the surface of oligodendrocytes and the outermost surface of myelin sheaths. [1] Its function is not entirely known. [1]

  5. Inflammatory demyelinating diseases of the central nervous ...

    en.wikipedia.org/wiki/Inflammatory_demyelinating...

    The anti-mog spectrum in children is equally variated: Out of a sample of 41 children with MOG-antibodies 29 had clinical NMOSD (17 relapsing), 8 had ADEM (4 relapsing with ADEM-ON), 3 had a single clinical event CIS, and 1 had a relapsing tumefactive disorder. Longitudinal myelitis was evident on MRI in 76[percent].

  6. Chronic relapsing inflammatory optic neuropathy - Wikipedia

    en.wikipedia.org/wiki/Chronic_relapsing...

    As of 2019, the correlation between CRION and MOG antibody-associated encephalomyelitis is so high that now CRION is considered the most common phenotype related to myelin oligodendrocyte glycoprotein antibodies (MOG-IgG). [9] As of 2021, some reports point out a second kind of CRION due to anti-phospholipid antibodies. [10]

  7. Acute disseminated encephalomyelitis - Wikipedia

    en.wikipedia.org/wiki/Acute_disseminated...

    Another variant of ADEM in adults has been described, also related to anti-MOG auto-antibodies, has been named fulminant disseminated encephalomyelitis, and it has been reported to be clinically ADEM, but showing MS-like lesions on autopsy. [19] It has been classified inside the anti-MOG associated inflammatory demyelinating diseases. [56]

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