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Phenylbutazone, often referred to as "bute", [1] is a nonsteroidal anti-inflammatory drug (NSAID) for the short-term treatment of pain and fever in animals.. In the United States and United Kingdom, it is no longer approved for human use (except in the United Kingdom for ankylosing spondylitis), as it can cause severe adverse effects such as suppression of white blood cell production and ...
Flunixin is a nonsteroidal anti-inflammatory drug (NSAID), analgesic, and antipyretic used in horses, cattle and pigs. It is often formulated as the meglumine salt.In the United States, it is regulated by the U.S. Food and Drug Administration (FDA), and may only be lawfully distributed by order of a licensed veterinarian.
It is a prodrug of the non-steroidal anti-inflammatory drug (NSAID) phenylbutazone, [1] and is commonly used in horses. [2] Synthesis
Phenylbutazone was formerly used as treatment, but when administered to horses at high doses, it can cause ulcers of the glandular stomach, oral cavity and colon. [10] Due to the major adverse effects of phenylbutazone, the replacement by tepoxalin was made to reduce muscular pain in 2003.
Clenbuterol is occasionally referred to as "bute" and this risks confusion with phenylbutazone, also called "bute". Phenylbutazone, which is a drug also used with horses, was tested for in the 2013 European meat adulteration scandal. [19]
However, this side effect does not occur with all drugs in the NSAID class, including phenylbutazone. [22] Diclofenac is a topical NSAID. It has a clear benefit over traditional NSAIDs in that topical application reduces the amount of drug circulating systemically, and therefore reduces the risk of negative side effects.
Weight loss medications like Contrave (a combination of naltrexone and bupropion) block the reward pathways that make it tempting to binge eat, but there are side effects.
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