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An agouti dog, also called wolf sable. In dogs, the agouti gene is associated with various coat colors and patterns. [10]The alleles at the A locus are related to the production of agouti-signaling protein (ASIP) and determine whether an animal expresses an agouti appearance and, by controlling the distribution of pigment in individual hairs, what type of agouti.
Agouti-signaling protein is a protein that in humans is encoded by the ASIP gene. [5] [6] It is responsible for the distribution of melanin pigment in mammals.[7] [8] Agouti interacts with the melanocortin 1 receptor to determine whether the melanocyte (pigment cell) produces phaeomelanin (a red to yellow pigment), or eumelanin (a brown to black pigment). [9]
A cat hair showing agouti coloration A domestic rabbit with agouti coloration. Agouti is a type of fur coloration in which each hair displays two or more bands of pigmentation. [1] [2] The overall appearance of agouti fur is usually gray or dull brown, [3] although dull yellow is also possible.
The name "agouti" is derived from either Guarani or Tupi, both South American indigenous languages, in which the name is written variously as agutí, agoutí, acutí, [7] akuti and akuri. [8] The Portuguese term for these animals, cutia , is derived from this original naming.
Agouti-signalling protein or ASIP, a circulating hormone encoded by the agouti gene that acts as an antagonist at melanocortin receptors; Agouti-related peptide, a neuropeptide produced in the brain by the AgRP/NPY neuron; Agouti coloration genetics, discussing coat colors created by differences in the agouti gene
There is a gene not yet identified, but believed to be related to the agouti gene in the Chausie breed that produces silver-tipped black fur similar to Abyssinian ticked fur, known as "grizzled". This phenomenon is purported to have been inherited from the hybridization of the domestic cat to the jungle cat ( Felis chaus ).
A change at the agouti locus is capable of turning bay to black, while a mutation at the extension locus can turn bay or black to chestnut. These three "base" colors can be affected by any number of dilution genes and patterning genes. The dilution genes include the wildtype dun gene, believed to be one of the oldest colors extant in horses and ...
Meanwhile, the agouti gene determines whether the cells can stop producing black. The A version of agouti means that it can, so as long as has E at extension the base color will be bay. The a version of agouti means the cells cannot stop producing black, so a horse with two copies of a (genotype a/a) and E at extension will be black rather than ...