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Rhabdomyolysis may cause kidney failure by several mechanisms. The most important is the accumulation of myoglobin in the kidney tubules. [10] [11] [13] Normally, the blood protein haptoglobin binds circulating myoglobin and other heme-containing substances, but in rhabdomyolysis the quantity of myoglobin exceeds the binding capacity of ...
AKI - the other main type of kidney disease - can be caused by dehydration, blood loss, urinary tract obstructions such as kidney stones or blood clots, low blood pressure, or heart disease. It ...
Chronic kidney disease results in worse all-cause mortality (the overall death rate) which increases as kidney function decreases. [86] The leading cause of death in chronic kidney disease is cardiovascular disease, regardless of whether there is progression to stage 5. [86] [87] [88]
Late untreated crush syndrome death is caused by renal failure, coagulopathy and hemorrhage, and sepsis. [ 11 ] Due to the risk of crush syndrome, current recommendation to nonprofessional first-aiders (in the UK) is to not release those with a crush injury who have been trapped for more than 15 minutes. [ 12 ]
Kidney ischemia [1] is a disease with a high morbidity and mortality rate. [2] Blood vessels shrink and undergo apoptosis which results in poor blood flow in the kidneys. More complications happen when failure of the kidney functions result in toxicity in various parts of the body which may cause septic shock, hypovolemia, and a need for surgery. [3]
Very low levels of azotemia may produce few, if any, symptoms. If the disease progresses, symptoms become noticeable (if the failure is of sufficient degree to cause symptoms). Kidney failure accompanied by noticeable symptoms is termed uraemia. [18] Symptoms of kidney failure include the following: [18] [19] [20] [21]
High blood pressure is estimated to cause 7.5 million deaths worldwide each year, according to the World Health Organization. Diabetes exerts a similar kind of long-term toll on the body.
Rates for both chronic kidney disease and mortality have increased, associated with the rising prevalence of diabetes and the ageing global population. [ 2 ] [ 3 ] The World Health Organization has reported that "kidney diseases have risen from the world’s nineteenth leading cause of death to the ninth, with the number of deaths increasing by ...